Recent Advances in Nucleosides: Chemistry and ChemotherapyElsevier, 11 set 2002 - 544 pagine The book covers up-to-date information on nucleosides and antiviral chemotherapy contributed by the world experts in the field of nucleoside. This book is the result of a meeting honoring Dr. Jack J. Fox, who was one of the pioneers in nucleoside chemistry and chemotherapy. This book consists of 15 excellent chapters in the area, which include topics from recent synthetic methodologies, nucleoside kinase implicated in chemotherapy and drug design, excellent reviews on antiviral agents, nucleoside metabolism/mode of action in parasites, new compounds under clinical and pre-clinical trials, IMPDH inhibitors to review on nucleoside prodrugs. |
Sommario
| 1 | |
| 21 | |
Chapter 3 Synthesis of purine acyclonucleosides via ribofuranosering cleavage of purine nucleosides by diisobutylaluminum hydride | 57 |
Chapter 4 The chemistry of nucleoside and dinucleotide inhibitors of nosine monophosphate dehydrogenase IMPDH | 71 |
Chapter 5 Nucleoside and nucleotide prodrugs | 91 |
discovery chemisry and chemical biology | 149 |
Chapter 7 Synthesis and biological activity of isopolar acyclic nucleotide analogs | 167 |
Chapter 8 Synthesis of pyranose nucleosides and related nucleosides with a sixmembered carbohydrate mimic | 239 |
chemistry and biological activity | 327 |
Chapter 12 Lithiationbased silylation and stannylation for nucleoside synthesis | 359 |
potential targets for chemotherapy | 377 |
Chapter 14 Antiviral βLnucleosides specific for hepatits B virus infection | 417 |
the BVDU connection | 433 |
Chapter 16 The role of the cellular deoxynucleoside kinases in activation of nucleoside analogs used in chemotherapy | 455 |
Chapter 17 Cellular transport of nucleotide analogs | 477 |
synthesis and properties of nucleosides and oligonucleotides | 505 |
Chapter 9 5Norcarbanucleosides in Llike configurations | 291 |
Chapter 10 Tricyclic nucleosides revisited | 299 |
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acid acyclic addition adefovir adenine adenosine Agents Agents Chemother analogues anion ANPs anti-HIV Antimicrob antiviral activity approach Balzarini base Biochem Biol biological BVDU cells Chem Chemistry cidofovir Clercq clinical Commun compared compounds concentration containing derivatives designed drug effect efficient enzyme ester et al expression Figure followed function gave give half-life heterocyclic Holy human Imbach increased infection inhibition inhibitors kinase Lett levels mechanism MeOH metabolism method mixture moiety Nair novel nucleobase nucleoside nucleoside analogues obtained oral organic parasites parent Pharmacol phosphonate phosphorylation PMEA potent prepared presence prodrugs properties protected purine purine nucleosides pyrimidine radical reaction recently reduction resistance respectively ring Scheme selective showed shown similar specific structure studies substrate sugar Synthesis Table Tetrahedron thymidine toxicity transport treatment uptake virus vitro Wang Watanabe yield
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Pagina 51 - Monia, BP, Johnston, JF, Ecker, DJ, Zounes, MA, Lima, WF, and Freier, SM (1992) Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides. J. Biol. Chem. 267, 19954-19962.
Pagina 48 - Deoxynucleoside phosphoramidites — a new class of key intermediates for deoxypolynucleotide synthesis.