PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 272
... normal area at the expense of the ischaemic area ( in which the arterioles are anyway fully dilated ) . 1 △ -Depolarizing- △ step Fig . 14.16 Mode behaviour. the reduced stroke output is largely compensated by reflex tachycardia , so ...
... normal area at the expense of the ischaemic area ( in which the arterioles are anyway fully dilated ) . 1 △ -Depolarizing- △ step Fig . 14.16 Mode behaviour. the reduced stroke output is largely compensated by reflex tachycardia , so ...
Pagina 400
... normal gene that codes for leptin , ' lep ' , and reserve the term ob for the mutated gene ) . Leptin is found in the blood of normal mice but not of genetically obese oblob mice , and when recombinant leptin is given intraperitoneally ...
... normal gene that codes for leptin , ' lep ' , and reserve the term ob for the mutated gene ) . Leptin is found in the blood of normal mice but not of genetically obese oblob mice , and when recombinant leptin is given intraperitoneally ...
Pagina 668
... normal cells thus enabling them to establish themselves ' extraterritorially ' . THE GENESIS OF A CANCER CELL A normal cell turns into a cancer cell because of a muta- tion in its DNA , which can be inherited * or acquired . The ...
... normal cells thus enabling them to establish themselves ' extraterritorially ' . THE GENESIS OF A CANCER CELL A normal cell turns into a cancer cell because of a muta- tion in its DNA , which can be inherited * or acquired . The ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular