WO2001055364A3 - Nucleic acids, proteins, and antibodies - Google Patents

Nucleic acids, proteins, and antibodies Download PDF

Info

Publication number
WO2001055364A3
WO2001055364A3 PCT/US2001/001308 US0101308W WO0155364A3 WO 2001055364 A3 WO2001055364 A3 WO 2001055364A3 US 0101308 W US0101308 W US 0101308W WO 0155364 A3 WO0155364 A3 WO 0155364A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
antibodies
novel
further relates
present
Prior art date
Application number
PCT/US2001/001308
Other languages
French (fr)
Other versions
WO2001055364A2 (en
WO2001055364A8 (en
Inventor
Craig A Rosen
Steven C Barash
Steven M Ruben
Original Assignee
Human Genome Sciences Inc
Craig A Rosen
Steven C Barash
Steven M Ruben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Craig A Rosen, Steven C Barash, Steven M Ruben filed Critical Human Genome Sciences Inc
Priority to AU3646001A priority Critical patent/AU3646001A/en
Priority to EP01908612A priority patent/EP1254217A2/en
Publication of WO2001055364A2 publication Critical patent/WO2001055364A2/en
Publication of WO2001055364A8 publication Critical patent/WO2001055364A8/en
Publication of WO2001055364A3 publication Critical patent/WO2001055364A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypetides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production of the polypeptides of the present invention.
PCT/US2001/001308 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies WO2001055364A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU3646001A AU3646001A (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
EP01908612A EP1254217A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies

Applications Claiming Priority (235)

Application Number Priority Date Filing Date Title
US17906500P 2000-01-31 2000-01-31
US60/179,065 2000-01-31
US18062800P 2000-02-04 2000-02-04
US60/180,628 2000-02-04
US18466400P 2000-02-24 2000-02-24
US60/184,664 2000-02-24
US18635000P 2000-03-02 2000-03-02
US60/186,350 2000-03-02
US18987400P 2000-03-16 2000-03-16
US60/189,874 2000-03-16
US19007600P 2000-03-17 2000-03-17
US60/190,076 2000-03-17
US19812300P 2000-04-18 2000-04-18
US60/198,123 2000-04-18
US20551500P 2000-05-19 2000-05-19
US60/205,515 2000-05-19
US20946700P 2000-06-07 2000-06-07
US60/209,467 2000-06-07
US21488600P 2000-06-28 2000-06-28
US60/214,886 2000-06-28
US21513500P 2000-06-30 2000-06-30
US60/215,135 2000-06-30
US21688000P 2000-07-07 2000-07-07
US21664700P 2000-07-07 2000-07-07
US60/216,880 2000-07-07
US60/216,647 2000-07-07
US21748700P 2000-07-11 2000-07-11
US21749600P 2000-07-11 2000-07-11
US60/217,487 2000-07-11
US60/217,496 2000-07-11
US21829000P 2000-07-14 2000-07-14
US60/218,290 2000-07-14
US22096400P 2000-07-26 2000-07-26
US22096300P 2000-07-26 2000-07-26
US60/220,964 2000-07-26
US60/220,963 2000-07-26
US22521300P 2000-08-14 2000-08-14
US22521400P 2000-08-14 2000-08-14
US22544700P 2000-08-14 2000-08-14
US22526600P 2000-08-14 2000-08-14
US22526800P 2000-08-14 2000-08-14
US22451900P 2000-08-14 2000-08-14
US22575900P 2000-08-14 2000-08-14
US22451800P 2000-08-14 2000-08-14
US22575700P 2000-08-14 2000-08-14
US22526700P 2000-08-14 2000-08-14
US22575800P 2000-08-14 2000-08-14
US22527000P 2000-08-14 2000-08-14
US60/225,759 2000-08-14
US60/225,270 2000-08-14
US60/225,757 2000-08-14
US60/225,214 2000-08-14
US60/225,268 2000-08-14
US60/224,518 2000-08-14
US60/225,266 2000-08-14
US60/224,519 2000-08-14
US60/225,213 2000-08-14
US60/225,758 2000-08-14
US60/225,267 2000-08-14
US60/225,447 2000-08-14
US22627900P 2000-08-18 2000-08-18
US60/226,279 2000-08-18
US22686800P 2000-08-22 2000-08-22
US22668100P 2000-08-22 2000-08-22
US22718200P 2000-08-22 2000-08-22
US60/226,868 2000-08-22
US60/227,182 2000-08-22
US60/226,681 2000-08-22
US22700900P 2000-08-23 2000-08-23
US60/227,009 2000-08-23
US22892400P 2000-08-30 2000-08-30
US60/228,924 2000-08-30
US22934300P 2000-09-01 2000-09-01
US22934500P 2000-09-01 2000-09-01
US22934400P 2000-09-01 2000-09-01
US22928700P 2000-09-01 2000-09-01
US60/229,343 2000-09-01
US60/229,344 2000-09-01
US60/229,287 2000-09-01
US60/229,345 2000-09-01
US22950900P 2000-09-05 2000-09-05
US22951300P 2000-09-05 2000-09-05
US60/229,513 2000-09-05
US60/229,509 2000-09-05
US23043700P 2000-09-06 2000-09-06
US23043800P 2000-09-06 2000-09-06
US60/230,438 2000-09-06
US60/230,437 2000-09-06
US23124400P 2000-09-08 2000-09-08
US23124300P 2000-09-08 2000-09-08
US23124200P 2000-09-08 2000-09-08
US23208000P 2000-09-08 2000-09-08
US23208100P 2000-09-08 2000-09-08
US23141400P 2000-09-08 2000-09-08
US23141300P 2000-09-08 2000-09-08
US60/231,244 2000-09-08
US60/232,080 2000-09-08
US60/232,081 2000-09-08
US60/231,242 2000-09-08
US60/231,243 2000-09-08
US60/231,414 2000-09-08
US60/231,413 2000-09-08
US23196800P 2000-09-12 2000-09-12
US60/231,968 2000-09-12
US23239700P 2000-09-14 2000-09-14
US23240000P 2000-09-14 2000-09-14
US23240100P 2000-09-14 2000-09-14
US23306500P 2000-09-14 2000-09-14
US23306300P 2000-09-14 2000-09-14
US23306400P 2000-09-14 2000-09-14
US23239800P 2000-09-14 2000-09-14
US23239900P 2000-09-14 2000-09-14
US60/233,063 2000-09-14
US60/232,400 2000-09-14
US60/232,401 2000-09-14
US60/233,065 2000-09-14
US60/232,397 2000-09-14
US60/233,064 2000-09-14
US60/232,398 2000-09-14
US60/232,399 2000-09-14
US23422300P 2000-09-21 2000-09-21
US23427400P 2000-09-21 2000-09-21
US60/234,274 2000-09-21
US60/234,223 2000-09-21
US23499700P 2000-09-25 2000-09-25
US23499800P 2000-09-25 2000-09-25
US60/234,998 2000-09-25
US60/234,997 2000-09-25
US23548400P 2000-09-26 2000-09-26
US60/235,484 2000-09-26
US23583600P 2000-09-27 2000-09-27
US23583400P 2000-09-27 2000-09-27
US60/235,834 2000-09-27
US60/235,836 2000-09-27
US23632700P 2000-09-29 2000-09-29
US23636800P 2000-09-29 2000-09-29
US23636700P 2000-09-29 2000-09-29
US23636900P 2000-09-29 2000-09-29
US23637000P 2000-09-29 2000-09-29
US60/236,370 2000-09-29
US60/236,367 2000-09-29
US60/236,368 2000-09-29
US60/236,327 2000-09-29
US60/236,369 2000-09-29
US23703700P 2000-10-02 2000-10-02
US23703800P 2000-10-02 2000-10-02
US23704000P 2000-10-02 2000-10-02
US23703900P 2000-10-02 2000-10-02
US23680200P 2000-10-02 2000-10-02
US60/237,040 2000-10-02
US60/237,039 2000-10-02
US60/236,802 2000-10-02
US60/237,037 2000-10-02
US60/237,038 2000-10-02
US23993500P 2000-10-13 2000-10-13
US23993700P 2000-10-13 2000-10-13
US60/239,935 2000-10-13
US60/239,937 2000-10-13
US24178700P 2000-10-20 2000-10-20
US24178500P 2000-10-20 2000-10-20
US24182600P 2000-10-20 2000-10-20
US24096000P 2000-10-20 2000-10-20
US24180900P 2000-10-20 2000-10-20
US24122100P 2000-10-20 2000-10-20
US24180800P 2000-10-20 2000-10-20
US24178600P 2000-10-20 2000-10-20
US60/241,808 2000-10-20
US60/241,221 2000-10-20
US60/241,787 2000-10-20
US60/240,960 2000-10-20
US60/241,809 2000-10-20
US60/241,786 2000-10-20
US60/241,785 2000-10-20
US60/241,826 2000-10-20
US24461700P 2000-11-01 2000-11-01
US60/244,617 2000-11-01
US24652500P 2000-11-08 2000-11-08
US24653200P 2000-11-08 2000-11-08
US24647500P 2000-11-08 2000-11-08
US24652800P 2000-11-08 2000-11-08
US24647600P 2000-11-08 2000-11-08
US24661100P 2000-11-08 2000-11-08
US24652600P 2000-11-08 2000-11-08
US24652700P 2000-11-08 2000-11-08
US24647400P 2000-11-08 2000-11-08
US24647700P 2000-11-08 2000-11-08
US24661000P 2000-11-08 2000-11-08
US60/246,476 2000-11-08
US60/246,528 2000-11-08
US60/246,478 2000-11-08
US60/246,475 2000-11-08
US60/246,523 2000-11-08
US60/246,477 2000-11-08
US60/246,474 2000-11-08
US60/246,609 2000-11-08
US60/246,613 2000-11-08
US60/246,611 2000-11-08
US60/246,527 2000-11-08
US60/246,525 2000-11-08
US60/246,526 2000-11-08
US60/246,610 2000-11-08
US60/246,524 2000-11-08
US60/246,532 2000-11-08
US60/249,300 2000-11-17
US60/249,216 2000-11-17
US60/249,299 2000-11-17
US60/249,215 2000-11-17
US60/249,297 2000-11-17
US60/249,213 2000-11-17
US60/249,214 2000-11-17
US60/249,245 2000-11-17
US60/249,218 2000-11-17
US60/249,212 2000-11-17
US60/249,244 2000-11-17
US60/249,207 2000-11-17
US60/249,208 2000-11-17
US60/249,265 2000-11-17
US60/249,209 2000-11-17
US60/249,217 2000-11-17
US60/249,264 2000-11-17
US60/249,211 2000-11-17
US60/249,210 2000-11-17
US60/250,160 2000-12-01
US60/250,391 2000-12-01
US60/251,988 2000-12-05
US60/251,030 2000-12-05
US60/256,719 2000-12-05
US60/251,479 2000-12-06
US60/251,989 2000-12-08
US60/251,856 2000-12-08
US60/251,868 2000-12-08
US60/251,869 2000-12-08
US60/251,990 2000-12-08
US60/254,097 2000-12-11
US60/259,678 2001-01-05

Publications (3)

Publication Number Publication Date
WO2001055364A2 WO2001055364A2 (en) 2001-08-02
WO2001055364A8 WO2001055364A8 (en) 2001-09-07
WO2001055364A3 true WO2001055364A3 (en) 2002-07-04

Family

ID=27587117

Family Applications (48)

Application Number Title Priority Date Filing Date
PCT/US2001/001321 WO2001055312A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001312 WO2001054733A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins and antibodies
PCT/US2001/001345 WO2001055325A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001357 WO2001055208A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001332 WO2001055318A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001313 WO2001055200A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001359 WO2001055328A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001341 WO2001055322A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001342 WO2001059064A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001335 WO2001055319A2 (en) 2000-01-31 2001-01-17 Endocrine related nucleic acids, proteins and antibodies
PCT/US2001/001325 WO2001055202A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001356 WO2001055173A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001315 WO2001055311A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001309 WO2001055308A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001333 WO2001055448A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001355 WO2001055207A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001324 WO2001055314A2 (en) 2000-01-31 2001-01-17 Digestive system related nucleic acids, proteins and antibodies
PCT/US2001/001314 WO2001055310A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001352 WO2001055327A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001310 WO2001055387A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001336 WO2001055204A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001311 WO2001055309A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001343 WO2001055323A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001338 WO2001055367A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001326 WO2001055315A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001239 WO2001055301A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001322 WO2001055343A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001308 WO2001055364A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001349 WO2001054474A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001306 WO2001055307A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001348 WO2001055368A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001350 WO2001055350A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001316 WO2001054473A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001240 WO2001055302A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001328 WO2001055316A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001317 WO2001055201A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001330 WO2001055447A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001344 WO2001055324A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001302 WO2001055304A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001337 WO2001055205A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001351 WO2001055355A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001301 WO2001055303A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001353 WO2001055206A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001339 WO2001055320A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001358 WO2001055163A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001340 WO2001055321A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001327 WO2001055203A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001354 WO2001057182A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies

Family Applications Before (27)

Application Number Title Priority Date Filing Date
PCT/US2001/001321 WO2001055312A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001312 WO2001054733A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins and antibodies
PCT/US2001/001345 WO2001055325A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001357 WO2001055208A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001332 WO2001055318A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001313 WO2001055200A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001359 WO2001055328A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001341 WO2001055322A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001342 WO2001059064A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001335 WO2001055319A2 (en) 2000-01-31 2001-01-17 Endocrine related nucleic acids, proteins and antibodies
PCT/US2001/001325 WO2001055202A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001356 WO2001055173A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001315 WO2001055311A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001309 WO2001055308A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001333 WO2001055448A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001355 WO2001055207A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001324 WO2001055314A2 (en) 2000-01-31 2001-01-17 Digestive system related nucleic acids, proteins and antibodies
PCT/US2001/001314 WO2001055310A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001352 WO2001055327A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001310 WO2001055387A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001336 WO2001055204A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001311 WO2001055309A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001343 WO2001055323A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001338 WO2001055367A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001326 WO2001055315A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001239 WO2001055301A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001322 WO2001055343A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies

Family Applications After (20)

Application Number Title Priority Date Filing Date
PCT/US2001/001349 WO2001054474A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001306 WO2001055307A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001348 WO2001055368A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001350 WO2001055350A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001316 WO2001054473A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001240 WO2001055302A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001328 WO2001055316A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001317 WO2001055201A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001330 WO2001055447A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001344 WO2001055324A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001302 WO2001055304A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001337 WO2001055205A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001351 WO2001055355A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001301 WO2001055303A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001353 WO2001055206A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001339 WO2001055320A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001358 WO2001055163A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001340 WO2001055321A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001327 WO2001055203A1 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies
PCT/US2001/001354 WO2001057182A2 (en) 2000-01-31 2001-01-17 Nucleic acids, proteins, and antibodies

Country Status (3)

Country Link
AU (16) AU2001241409A1 (en)
CA (37) CA2395724A1 (en)
WO (48) WO2001055312A2 (en)

Families Citing this family (270)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020137890A1 (en) 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7579160B2 (en) 1998-03-18 2009-08-25 Corixa Corporation Methods for the detection of cervical cancer
US7258860B2 (en) 1998-03-18 2007-08-21 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6960570B2 (en) 1998-03-18 2005-11-01 Corixa Corporation Compositions and methods for the therapy and diagnosis of lung cancer
US6706262B1 (en) 1998-03-18 2004-03-16 Corixa Corporation Compounds and methods for therapy and diagnosis of lung cancer
AU740405B2 (en) 1998-05-15 2001-11-01 Genentech Inc. IL-17 homologous polypeptides and therapeutic uses thereof
US7771719B1 (en) 2000-01-11 2010-08-10 Genentech, Inc. Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E
US6929938B2 (en) 2001-08-15 2005-08-16 Millennium Pharmaceuticals, Inc. 25501, a human transferase family member and uses therefor
US7141417B1 (en) 1999-02-25 2006-11-28 Thomas Jefferson University Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
JP2003508011A (en) * 1999-02-25 2003-03-04 トマス・ジエフアーソン・ユニバーシテイ Compositions, kits and methods relating to a novel tumor suppressor gene that is the human FEZ1 gene
WO2000050458A1 (en) * 1999-02-26 2000-08-31 Smithkline Beecham Corporation Cloning of a p2y-like 7tm receptor (axor17)
CA2365238A1 (en) * 1999-03-23 2000-09-28 Human Genome Sciences, Inc. 48 human secreted proteins
WO2000058480A1 (en) * 1999-03-29 2000-10-05 Kansai Technology Licensing Organization Co., Ltd. Novel cytidine deaminase
EP1637541B1 (en) * 1999-09-01 2010-03-03 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1228090A4 (en) * 1999-10-27 2003-01-22 Millennium Pharm Inc Novel molecules and the card-related protein family and uses thereof
US6893818B1 (en) 1999-10-28 2005-05-17 Agensys, Inc. Gene upregulated in cancers of the prostate
US7005499B1 (en) * 1999-11-18 2006-02-28 Genentech, Inc. Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same
EP1878795A3 (en) * 1999-11-30 2008-01-23 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
EP1690872A3 (en) * 1999-12-01 2006-08-23 Genentech, Inc. Composition and methods for the diagnosis of tumours
CN1300781A (en) * 1999-12-22 2001-06-27 上海博德基因开发有限公司 Polypeptide-human SHC protein 43 and polynucleotide for coding this polypeptide
US20040043397A1 (en) 2000-01-11 2004-03-04 Genentech, Inc. IL-17 homologous polypeptides and therapeutic uses thereof
ES2360155T3 (en) 2000-01-26 2011-06-01 Agensys, Inc. 84P2A9: A SPECIFIC PROTEIN OF PROSTATE AND TESTICLES HIGHLY EXPRESSED IN PROSTATE CANCER.
US6953682B2 (en) 2000-02-10 2005-10-11 Millennium Pharmaceuticals, Inc. Nucleic acid sequences encoding adenylate kinase, phospholipid scramblase-like, DNA fragmentation factor-like, phosphatidylserine synthase-like, and atpase-like molecules and uses therefor
US7078205B2 (en) 2000-02-17 2006-07-18 Millennium Pharmaceuticals, Inc. Nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, atpase molecules, acyltransferase molecules, pyridoxal-phosphate dependent enzyme molecules and uses therefor
US20020082212A1 (en) * 2000-07-20 2002-06-27 Millennium Pharmaceuticals, Inc. 7716, a novel human ATPase and uses therefor
US20020090705A1 (en) * 2000-07-14 2002-07-11 Rachel Meyers 62088, a novel human nucleoside phosphatase family member and uses thereof
US20020031815A1 (en) * 2000-06-26 2002-03-14 Millennium Pharmaceuticals, Inc. 46619, a novel human beta-ketoacyl synthase and uses thereof
US20020055159A1 (en) * 2000-06-15 2002-05-09 Meyers Rachel A. 23680,a novel human aminotransferase and uses therefor
US7718397B2 (en) 2000-03-21 2010-05-18 Genentech, Inc. Nucleic acids encoding receptor for IL-17 homologous polypeptides and uses thereof
EP1268791A2 (en) * 2000-03-23 2003-01-02 Immusol Incorporated Brca-1 regulators and methods of use
AU2001245974A1 (en) 2000-03-24 2001-10-08 Millennium Pharmaceuticals, Inc. 3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor
US20030198953A1 (en) * 2000-03-30 2003-10-23 Spytek Kimberly A. Novel proteins and nucleic acids encoding same
US7632929B2 (en) 2000-04-20 2009-12-15 The Board Of Trustees Of The University Of Arkansas Methamphetamine-like hapten compounds, linkers, carriers and compositions and uses thereof
AU5719501A (en) 2000-04-25 2001-11-07 Lexicon Genetics Inc Novel human kinase proteins and polynucleotides encoding the same
WO2001081586A2 (en) * 2000-04-26 2001-11-01 Millennium Pharmaceuticals, Inc. 21657, a human short-chain dehydrogenase and uses thereof
US6808876B1 (en) 2000-05-02 2004-10-26 Immusol, Inc. Cellular regulators of infectious agents and methods of use
JP2003532412A (en) * 2000-05-12 2003-11-05 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング Novel serine-threonine kinase-4
WO2001090160A2 (en) * 2000-05-26 2001-11-29 Bayer Aktiengesellschaft REGULATION OF HUMAN p78-LIKE SERINE/THREONINE KINASE
EP1158001B1 (en) * 2000-05-26 2007-11-14 F. Hoffmann-La Roche Ag A nucleic acid which is upregulated in human tumor cells, a protein encoded thereby and a process for tumor diagnosis
DE10027170A1 (en) * 2000-05-31 2001-12-13 Schering Ag Human PEM as a target for fertility control
US20030096969A1 (en) 2000-06-02 2003-05-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU6531101A (en) * 2000-06-02 2001-12-17 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001093805A2 (en) * 2000-06-02 2001-12-13 The Brigham & Women's Hospital, Inc. FUSION OF jAZF1 AND jjAZ1 GENES IN ENDOMETIRIAL STROMAL TUMORS
WO2001094385A2 (en) * 2000-06-05 2001-12-13 Bayer Aktiengesellschaft Human hm74-like g protein coupled receptor
US6323016B1 (en) 2000-06-09 2001-11-27 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
AU2001269766A1 (en) * 2000-06-09 2001-12-24 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer
JP2004513620A (en) * 2000-06-16 2004-05-13 インサイト・ゲノミックス・インコーポレイテッド Protein phosphatase
CA2648048A1 (en) * 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
US7094587B2 (en) 2000-06-27 2006-08-22 Millennium Pharmaceuticals, Inc. 16002 Molecules and uses therefor
JP2004501623A (en) * 2000-06-27 2004-01-22 キュラジェン　コーポレイション Polynucleotides and polypeptides encoded thereby
AU2001271621A1 (en) 2000-06-28 2002-01-08 Diadexus, Inc. Method of diagnosing, monitoring, staging, imaging and treating colon cancer
WO2002002761A2 (en) * 2000-06-30 2002-01-10 Millennium Pharmaceuticals, Inc. 57658, a human uridine kinase and uses thereof
WO2002004520A2 (en) * 2000-07-07 2002-01-17 Incyte Genomics, Inc. Transporters and ion channels
WO2002004510A2 (en) * 2000-07-07 2002-01-17 Incyte Genomics, Inc. Gtp-binding proteins
US20030171324A1 (en) * 2000-07-18 2003-09-11 Shyam Ramakrishnan Regulation of human desc1-like serine protease
WO2002006318A2 (en) 2000-07-18 2002-01-24 Board Of Regents, The University Of Texas System Methods and compositions for stabilizing microtubules and intermediate filaments in striated muscle cells
EP1354040A2 (en) * 2000-07-20 2003-10-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU8762901A (en) * 2000-07-25 2002-02-05 Merck Patent Gmbh Novel protein containing ring finger domaine r1p4
AU2001277200A1 (en) * 2000-07-26 2002-02-05 Applied Genomics, Inc. Bstp-cad protein and related reagents and methods of use thereof
AU2001277202A1 (en) * 2000-07-26 2002-02-05 Applied Genomics, Inc. Bstp-ras/rerg protein and related reagents and methods of use thereof
US7335732B2 (en) 2000-08-01 2008-02-26 Genentech, Inc. PRO9799 polypeptides
EP1657254A3 (en) * 2000-08-01 2006-06-07 Genentech, Inc. Polypeptide, nucleic acid encoding it, and their use for the diagnosis of cancer
EP1315431A1 (en) * 2000-08-02 2003-06-04 Millennium Pharmaceuticals, Inc. A human gtp-releasing factor family member (15368) and uses therefor
US7402660B2 (en) 2000-08-02 2008-07-22 The Johns Hopkins University Endothelial cell expression patterns
WO2002012330A2 (en) * 2000-08-04 2002-02-14 Zymogenetics, Inc. Human secreted protein, zzp1
WO2002012285A2 (en) * 2000-08-10 2002-02-14 Board Of Regents, The University Of Texas System The tumor suppressor car-1
AU9174501A (en) * 2000-08-11 2002-02-25 Merck Patent Gmbh Novel mitogen activated kinase
EP1326985A1 (en) * 2000-08-18 2003-07-16 MERCK PATENT GmbH Identification of a human n-terminal acetyltransferase gene
WO2002016586A2 (en) * 2000-08-21 2002-02-28 Bristol-Myers Squibb Company Adenosine deaminase homolog
WO2002016587A2 (en) * 2000-08-21 2002-02-28 Incyte Genomics, Inc. Microtubule-associated proteins and tubulins
WO2002016579A2 (en) * 2000-08-24 2002-02-28 Eli Lilly And Company Nucleic acids, vectors, host cells, polypeptides and uses thereof
US7217799B2 (en) * 2000-08-28 2007-05-15 Agensys, Inc. Antibodies that recognize the 85P1B3 protein useful in treatment and detection of cancer
WO2002018568A2 (en) * 2000-08-28 2002-03-07 Astrazeneca Ab Molecules involved in the regulation of insulin in resistance syndrome (irs)
EP1313761A4 (en) * 2000-08-28 2005-01-26 Human Genome Sciences Inc 18 human secreted proteins
WO2002018567A2 (en) * 2000-08-30 2002-03-07 Bayer Aktiengesellschaft Regulation of human aminotransferase-like enzyme
AU2001285908A1 (en) * 2000-08-30 2002-03-13 Bayer Aktiengesellschaft Regulation of human aminotransferase-like enzyme
WO2002018573A2 (en) * 2000-08-30 2002-03-07 Millennium Pharmaceuticals, Inc. 54370, a novel human sulfate transporter and uses therefor
US20020146800A1 (en) * 2000-08-30 2002-10-10 Curtis Rory A.J. 48921, a novel human GTP releasing factor and uses therefor
WO2002018582A2 (en) * 2000-08-31 2002-03-07 Millennium Pharmaceuticals, Inc. 62112, a novel human dehydrogenase and uses thereof
JP2004508043A (en) 2000-09-05 2004-03-18 アムジェン　インコーポレイテッド TNF receptor-like molecules and uses thereof
WO2002020754A2 (en) * 2000-09-05 2002-03-14 Incyte Genomics, Inc. Molecules for diagnostics and therapeutics
WO2002020765A2 (en) * 2000-09-08 2002-03-14 Millennium Pharmaceuticals, Inc. 38646, a guanine nucleotide exchange factor and uses therefor
US6372468B1 (en) 2000-09-14 2002-04-16 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US6391606B1 (en) * 2000-09-14 2002-05-21 Pe Corporation Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
JP2004531203A (en) * 2000-10-05 2004-10-14 キュラジェン コーポレイション Human proteins, polynucleotides encoding them, and methods of using them
AU2002211597A1 (en) * 2000-10-11 2002-04-22 Millennium Pharmaceuticals, Inc. 8843, a human dual specificity phosphatase family member and uses therefor
AU2002220613A1 (en) * 2000-10-11 2002-04-22 Bayer Aktiengesellschaft Regulation of human cyclophilin-type peptidyl-prolyl cis-trans isomerase
AU2002211715A1 (en) * 2000-10-12 2002-04-22 The Texas A And M University System Nucleic acid sequences encoding cmg proteins cmg proteins and methods for their use
WO2002030268A2 (en) * 2000-10-13 2002-04-18 Eos Biotechnology, Inc. Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer
US6531297B2 (en) * 2000-10-20 2003-03-11 Applera Corporation Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
EP1385861A2 (en) 2000-10-25 2004-02-04 Diadexus, Inc. Compositions and methods relating to lung specific genes and proteins
AU2002220668A1 (en) * 2000-10-31 2002-05-15 Bayer Aktiengesellschaft Regulation of human glutathione-s-transferase
AU2002229011A1 (en) * 2000-11-09 2002-05-21 Glaxo Group Limited Deaminase catalyzing the removal of the cyclopropyl moiety from abacavir-mp
US6855517B2 (en) 2000-11-20 2005-02-15 Diadexus, Inc. Compositions and methods relating to breast specific genes and proteins
AU2001297765A1 (en) * 2000-12-05 2002-10-21 Incyte Genomics, Inc. Ligases
CA2430379A1 (en) 2000-12-07 2002-06-13 Chiron Corporation Endogenous retroviruses up-regulated in prostate cancer
CA2429959A1 (en) 2000-12-07 2002-06-13 Zymogenetics, Inc. Adipocyte complement related protein zacrp3x2
CA2439800A1 (en) * 2000-12-14 2002-06-20 Pe Corporation (Ny) Isolated human kinase proteins, their encoding nucleic acid molecules, and uses thereof
US20020142376A1 (en) * 2000-12-20 2002-10-03 Gennady Merkulov Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
MXPA03005500A (en) 2000-12-22 2004-04-20 Bristol Myers Squibb Co A novel human leucine-rich repeat containing protein expressed predominately in small intestine, hlrrsi1.
US7892730B2 (en) * 2000-12-22 2011-02-22 Sagres Discovery, Inc. Compositions and methods for cancer
US6423521B1 (en) 2000-12-28 2002-07-23 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
WO2002053591A1 (en) * 2000-12-30 2002-07-11 Lion Bioscience Ag Mammalian nuclear receptor cofactor cf12 and methods of use
AU2002236717A1 (en) * 2001-01-08 2002-07-16 Lexicon Genetics Incorporated Human protease and polynucleotides encoding the same
CA2436661A1 (en) * 2001-01-30 2002-08-08 Regeneron Pharmaceuticals, Inc. Novel nucleic acid and polypeptide molecules
EP1409536A2 (en) * 2001-02-12 2004-04-21 Curagen Corporation Human proteins and nucleic acids encoding same
EP1637601A3 (en) * 2001-02-21 2006-03-29 Curagen Corporation Proteins, polynucleotides encoding them and methods of using the same
US7271240B2 (en) 2001-03-14 2007-09-18 Agensys, Inc. 125P5C8: a tissue specific protein highly expressed in various cancers
EP1434783A4 (en) * 2001-03-16 2006-06-07 Lilly Co Eli Lp mammalian proteins; related reagents
US6913904B2 (en) * 2001-03-27 2005-07-05 Applera Corporation Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof
CA2443123A1 (en) 2001-04-10 2002-10-24 Agensys, Inc. Nuleic acids and corresponding proteins useful in the detection and treatment of various cancers
PT1573022E (en) 2001-04-10 2011-08-23 Agensys Inc Nucleic acid and corresponding protein entitled 184p1e2 useful in treatment and detection of cancer
EP1383922A4 (en) 2001-04-10 2005-03-30 Agensys Inc Nucleid acid and corresponding protein entitled 158p3d2 useful in treatment and detection of cancer
JP2004532030A (en) * 2001-04-24 2004-10-21 イシス・イノベイション・リミテッド Disease enzymes and SNP markers
KR20040015128A (en) * 2001-04-24 2004-02-18 오츠카 세이야쿠 가부시키가이샤 Crohn's disease antibody-binding peptide and method of examining crohn's disease
JP4112374B2 (en) 2001-05-07 2008-07-02 塩野義製薬株式会社 Polypeptides and DNAs for angiogenesis markers
AU2002314048A1 (en) * 2001-05-09 2002-11-18 Bayer Aktiengesellschaft Regulation of human phosphatidic acid phosphatase type 2c-like protein
US6905827B2 (en) 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
AU2002311535A1 (en) * 2001-06-26 2003-01-08 Decode Genetics Ehf. Nucleic acids encoding protein kinases
US20030120040A1 (en) 2001-06-29 2003-06-26 Genentech, Inc. Secreted and Transmembrane polypeptides and nucleic acids encoding the same
GB2399087A (en) * 2001-08-02 2004-09-08 Aeomica Inc Human zinc finger containing gene MDZ7
WO2003031568A2 (en) * 2001-08-17 2003-04-17 Incyte Genomics, Inc. Intracellular signaling molecules
US7270960B2 (en) * 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
WO2003023063A1 (en) * 2001-09-07 2003-03-20 Sankyo Company, Limited Method of judging onset risk of diabetes
WO2003025175A2 (en) * 2001-09-17 2003-03-27 Molecular Engines Laboratories Sequences involved in phenomena of tumour suppression, tumour reversion, apoptosis and/or virus resistance and their use as medicines
WO2003040369A2 (en) * 2001-09-17 2003-05-15 Molecular Engines Laboratories Sequences involved in tumoral suppression, tumoral reversion, apoptosis and/or viral resistance phenomena and their use as medicines
US7179627B2 (en) 2001-09-28 2007-02-20 Brigham Young University Cyclooxygenase variants and methods of use
EP1439225A4 (en) 2001-10-04 2005-10-26 Kansai Tech Licensing Org Co Dr5 gene promoter and siah-1 gene promoter
US7084257B2 (en) 2001-10-05 2006-08-01 Amgen Inc. Fully human antibody Fab fragments with human interferon-gamma neutralizing activity
WO2003031607A1 (en) * 2001-10-10 2003-04-17 Bayer Healthcare Ag Regulation of human short-chain dehydrogenase/reductase
ATE364690T1 (en) 2001-11-09 2007-07-15 Proteologics Inc POSH NUCLEIC ACID, POLYPEPTIDES AND RELATED METHODS
WO2003054146A2 (en) 2001-11-14 2003-07-03 Northwestern University Self-assembly and mineralization of peptide-amphiphile nanofibers
US20050053940A1 (en) * 2001-11-21 2005-03-10 Joh-E Ikeda Huntington's disease gene transcriptional factors
US7151162B2 (en) 2001-12-06 2006-12-19 The University Of Children's Hospital Of Both Cantons Of Basel Nuclear protein
AU2002339697A1 (en) * 2001-12-19 2003-06-30 Genset S.A. Gmg-5 polynucleotides and polypeptides and uses thereof
JP2003245084A (en) 2001-12-20 2003-09-02 Morinaga Milk Ind Co Ltd New gene useful for diagnosis and treatment of aplasia of corpus callosum and aspermatogenesis and use thereof
DE10163467A1 (en) * 2001-12-21 2003-11-27 Axaron Bioscience Ag New DNA sequence encoding protein 24B2, useful for treatment and diagnosis or cancer and degenerative diseases, also related polypeptides and modulators
US6759222B2 (en) 2002-01-02 2004-07-06 Millennium Pharmaceuticals, Inc. 14815, a human kinase family member and uses therefor
WO2003057870A1 (en) * 2002-01-07 2003-07-17 Bayer Healthcare Ag Human phosphatidic acid phosphatase type 2-like protein
AU2003205611A1 (en) * 2002-01-15 2003-07-30 Medigene Ag Dilated cardiomyopathy associated gene-2 (dcmag-2): a cytoplasmatic inducer of sarcomeric remodeling in cardiomyocytes
AU2003235631A1 (en) * 2002-01-15 2003-07-30 Bayer Aktiengesellschaft Human subtilisin/kexin-like convertase
JPWO2003062429A1 (en) * 2002-01-23 2005-05-26 山之内製薬株式会社 New serine protease
AU2003215280A1 (en) 2002-02-15 2003-09-09 Northwestern University Self-assembly of peptide-amphiphile nanofibers under physiological conditions
EP1338609A1 (en) * 2002-02-21 2003-08-27 MEMOREC Stoffel GmbH-Medizinisch-Molekulare Entwicklung, Köln A further KDR receptor and the use thereof
EP1497311A2 (en) * 2002-03-05 2005-01-19 Applera Corporation Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
GB2388113A (en) * 2002-03-06 2003-11-05 Oxford Glycosciences B-cell malignancy-associated protein
ES2685702T3 (en) 2002-03-13 2018-10-10 Genomic Health, Inc. Obtaining gene expression profile in biopsied tumor tissues
AU2003220913A1 (en) * 2002-03-19 2003-09-29 Tanabe Seiyaku Co., Ltd. Novel g protein-coupled recepotrs and genes thereof
US7527935B2 (en) 2002-03-19 2009-05-05 Mitsubishi Tanabe Pharma Corporation G-protein coupled receptor having eicosanoid as ligand and gene thereof
GB0206684D0 (en) * 2002-03-21 2002-05-01 Babraham Inst Novel proteins
US7193069B2 (en) 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
CA2413475C (en) 2002-04-25 2010-07-27 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Zap-70 expression as a marker for chronic lymphocytic leukemia/small lymphocytic lymphoma (cll/sll)
JP2004041003A (en) * 2002-05-17 2004-02-12 Takeda Chem Ind Ltd New protein, its dna and use thereof
EP2275118A3 (en) 2002-05-29 2011-10-19 DeveloGen Aktiengesellschaft Pancreas-specific proteins
WO2003101401A2 (en) 2002-06-03 2003-12-11 Chiron Corporation Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancer
EP2233572A3 (en) * 2002-06-06 2011-01-12 Oncotherapy Science, Inc. Genes and polypeptides relating to human colon cancers
EP1532161B1 (en) 2002-06-13 2012-02-15 Novartis Vaccines and Diagnostics, Inc. Vectors for expression of hml-2 polypeptides
US20060172296A1 (en) * 2002-07-22 2006-08-03 Masahiro Takeuchi Novel gene associated with rheumatoid arthritis
CA2495177C (en) 2002-08-14 2014-01-21 National Institute Of Advanced Industrial Science And Technology Novel n-acetylgalactosamine transferases and nucleic acids encoding the same
AU2003243151A1 (en) * 2002-08-16 2004-03-03 Agensys, Inc. Nucleic acid and corresponding protein entitled 251p5g2 useful in treatment and detection of cancer
WO2004018518A1 (en) * 2002-08-23 2004-03-04 Japan Science And Technology Agency Human solid cancer antigen peptides, polynucleotides encoding the same and utilization thereof
EP1540014A2 (en) * 2002-08-27 2005-06-15 Epigenomics AG Method and nucleic acids for the analysis of breast cell proliferative disorders
US7452969B2 (en) 2002-08-30 2008-11-18 Licentia Ltd Neurotrophic factor protein and uses thereof
US7601826B2 (en) * 2002-09-30 2009-10-13 Oncotherapy Science, Inc. Genes and polypeptides relating to human pancreatic cancers
EP1552310A2 (en) * 2002-10-17 2005-07-13 EVOTEC Neurosciences GmbH Diagnostic and therapeutic use of the nicotinamide mononucleotide adenylyltransferase 2 (nmnat-2) gene and protein for neurodegenerative diseases
AU2002952216A0 (en) * 2002-10-23 2002-11-07 The Walter And Eliza Hall Institute Of Medical Research Novel therapeutic molecules
US7554021B2 (en) 2002-11-12 2009-06-30 Northwestern University Composition and method for self-assembly and mineralization of peptide amphiphiles
EP1570080A4 (en) 2002-11-15 2006-03-01 Genomic Health Inc Gene expression profiling of egfr positive cancer
DE10254601A1 (en) 2002-11-22 2004-06-03 Ganymed Pharmaceuticals Ag Gene products differentially expressed in tumors and their use
AU2003287764B2 (en) * 2002-12-13 2010-01-21 The Walter And Eliza Hall Institute Of Medical Research A novel phosphoprotein
AU2002953341A0 (en) * 2002-12-13 2003-01-09 The Walter And Eliza Hall Institute Of Medical Research A novel phosphoprotein
US20040231909A1 (en) 2003-01-15 2004-11-25 Tai-Yang Luh Motorized vehicle having forward and backward differential structure
US7326768B2 (en) 2003-02-05 2008-02-05 Juan Saus Goodpasture antigen-binding protein isoforms and protein misfolded-mediated disorders
EP1445614A1 (en) * 2003-02-06 2004-08-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) A method for the in vitro assessment of the progression status of an HIV virus in an invidual
US7074891B2 (en) * 2003-02-07 2006-07-11 Posco Leukocyte stimulating peptides
ATE412779T1 (en) 2003-02-20 2008-11-15 Genomic Health Inc USE OF INTRONIC RNA SEQUENCES TO QUANTIFY GENE EXPRESSION
CA2517953A1 (en) * 2003-03-04 2004-09-16 Astellas Pharma Inc. Novel gene relating to fibrotic conditions
SI1606409T1 (en) 2003-03-19 2011-01-31 Biogen Idec Inc Nogo receptor binding protein
ITRM20030149A1 (en) 2003-04-02 2004-10-03 Giuliani Spa ANTISENSE OLIGONUCLEOTIDES (ODN) FOR SMAD7 AND THEIR USE IN THE MEDICAL FIELD
EP2775000B1 (en) 2003-06-24 2016-11-09 Genomic Health, Inc. Prediction of likelihood of cancer recurrence
CA2531967C (en) 2003-07-10 2013-07-16 Genomic Health, Inc. Expression profile algorithm and test for cancer prognosis
JP4643450B2 (en) 2003-08-08 2011-03-02 株式会社ペルセウスプロテオミクス Cancer high expression gene
US20050136434A1 (en) * 2003-08-12 2005-06-23 Mai Xu Isolated heat-inducible cell surface protein and hyperthermia-based tumor immunotargeting therapy
US20070178458A1 (en) * 2003-09-05 2007-08-02 O'brien Philippa Methods of diagnosis and prognosis of ovarian cancer II
WO2005026314A2 (en) * 2003-09-10 2005-03-24 Japan Science And Technology Agency Group of genes differentially expressed in peripheral blood cells and diagnostic method and assay method using the same
EP1667712B1 (en) * 2003-10-02 2010-07-21 GlaxoSmithKline Biologicals S.A. B. pertussis antigens and use thereof in vaccination
CA2541006C (en) 2003-10-03 2015-02-17 Brigham And Women's Hospital Tim-3 polypeptides
WO2005040791A2 (en) * 2003-10-21 2005-05-06 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with somatostatin- and angiogenin-like peptide receptor (salpr)
US20050255560A1 (en) * 2003-11-21 2005-11-17 Zeren Gao Ztnf11, a tumor necrosis factor
CN1905892A (en) * 2003-12-05 2007-01-31 西北大学 Self-assembling peptide amphiphiles and related methods for growth factor delivery
KR20070000438A (en) 2003-12-23 2007-01-02 게노믹 헬쓰, 인코포레이티드 Universal amplification of fragmented rna
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
EP2497836B1 (en) * 2004-03-02 2015-01-14 The Johns Hopkins University Mutations of the PIK3CA gene in human cancers
TW200539890A (en) 2004-03-12 2005-12-16 Brigham & Womens Hospital Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function
WO2005090569A1 (en) * 2004-03-24 2005-09-29 The Council Of The Queensland Institute Of Medical Research Cancer and testis vsm1 and vsm2 nucleic acids, proteins and uses thereof
AU2005229434B2 (en) 2004-03-30 2010-09-30 Nsgene A/S Therapeutic use of a growth factor, NsG33
WO2005100606A2 (en) 2004-04-09 2005-10-27 Genomic Health, Inc. Gene expression markers for predicting response to chemotherapy
DE102004024617A1 (en) 2004-05-18 2005-12-29 Ganymed Pharmaceuticals Ag Differentially expressed in tumors gene products and their use
WO2005118832A2 (en) * 2004-06-01 2005-12-15 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with serum/glucocorticoid regulated kinase-like protein (sgkl)
EP1776136B1 (en) 2004-06-24 2012-10-03 Biogen Idec MA Inc. Treatment of conditions involving demyelination
US7587279B2 (en) 2004-07-06 2009-09-08 Genomic Health Method for quantitative PCR data analysis system (QDAS)
US7985831B2 (en) * 2004-08-05 2011-07-26 Toagosei Co., Ltd. Crohn's disease antibody epitope peptide and reagent for testing Crohn's disease
ES2778851T3 (en) 2004-11-05 2020-08-12 Genomic Health Inc Prediction of response to chemotherapy using gene expression markers
ES2384107T3 (en) 2004-11-05 2012-06-29 Genomic Health, Inc. Molecular indicators of breast cancer prognosis and treatment response prediction
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
KR101027427B1 (en) 2004-11-12 2011-04-11 젠코어 인코포레이티드 Fc VARIANTS WITH INCREASED BINDING TO FcRn
AU2006220765A1 (en) 2005-03-04 2006-09-14 Northwestern University Angiogenic heparin binding peptide amphiphiles
CA2608315C (en) * 2005-05-13 2014-08-05 Centre National De La Recherche Scientifique Use of a new gene coding for a new member of the mcm2-8 family in pharmaceutical compositions
EP2478917A1 (en) 2005-07-08 2012-07-25 Biogen Idec MA Inc. SP35 antibodies and uses thereof
EP1907589A4 (en) * 2005-07-26 2010-11-24 Siemens Healthcare Diagnostics Single nucleotide polymorphisms associated with susceptibility to cardiovascular disease
WO2007037601A1 (en) * 2005-09-28 2007-04-05 Knu-Industry Cooperation Foundation Polypeptide inhibiting transmigration of leukocytes or growth and/or metastasis of cancer cells, and fusion protein thereof
EP1790664A1 (en) 2005-11-24 2007-05-30 Ganymed Pharmaceuticals AG Monoclonal antibodies against claudin-18 for treatment of cancer
DE602005023550D1 (en) 2005-12-14 2010-10-21 Licentia Ltd Uses of a neurotrophic factor
KR20090111307A (en) * 2006-07-03 2009-10-26 엑손히트 써라퓨틱스 에스에이 Prostate specific transcripts and the use thereof for prostate cancer therapeutics and diagnostics
WO2008030559A2 (en) * 2006-09-08 2008-03-13 Corixa Corporation Methods, compositions, and kits for the detection and monitoring of colon cancer
US8076295B2 (en) 2007-04-17 2011-12-13 Nanotope, Inc. Peptide amphiphiles having improved solubility and methods of using same
US8999634B2 (en) * 2007-04-27 2015-04-07 Quest Diagnostics Investments Incorporated Nucleic acid detection combining amplification with fragmentation
GB0805159D0 (en) 2008-03-19 2008-04-23 Sancho Madrid David Immune modulation via C-type lectin
UA101810C2 (en) 2007-07-27 2013-05-13 Имматикс Биотекнолоджис Гмбх Novel immutotherapeutic methods in treatment of neuronal and brain tumors
US7863021B2 (en) * 2007-09-05 2011-01-04 Celera Corporation Genetic polymorphisms associated with rheumatoid arthritis, methods of detection and uses thereof
WO2009034661A1 (en) * 2007-09-12 2009-03-19 Toppan Printing Co., Ltd. Method for diagnosis and induction of resistance to virus
JP2011500047A (en) 2007-10-17 2011-01-06 ウニベルシダ・ドゥ・コルドバ Human somatostatin receptor type 5 isoforms produced by alternative processing and oligonucleotide pairs for their detection by PCR
EP2808343B8 (en) 2007-12-26 2020-01-15 Xencor, Inc. Fc variants with altered binding to FcRn
GB0803352D0 (en) * 2008-02-22 2008-04-02 Ntnu Technology Transfer As Oligopeptidic compounds and uses thereof
WO2009115612A1 (en) * 2008-03-21 2009-09-24 Universiteit Hasselt Biomarkers for rheumatoid arthritis
JP2011527572A (en) 2008-07-09 2011-11-04 バイオジェン・アイデック・エムエイ・インコーポレイテッド Composition comprising a LINGO antibody or fragment
JP5616888B2 (en) 2008-07-24 2014-10-29 エヌエスジーン・アクティーゼルスカブＮｓＧｅｎｅ Ａ／Ｓ Therapeutic use of growth factor METRNL
DK2172211T3 (en) 2008-10-01 2015-02-16 Immatics Biotechnologies Gmbh Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers
WO2010057069A1 (en) 2008-11-14 2010-05-20 Gen-Probe Incorporated Compositions, kits and methods for detection campylobacter nucleic acid
WO2010062960A2 (en) 2008-11-26 2010-06-03 Cedars-Sinai Medical Center METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE
WO2010066018A1 (en) * 2008-12-09 2010-06-17 Alethia Biotherapeutics Inc. Novel human endogenous retorviral erv3 variant and uses thereof for diagnosing ovarian cancer
US8450271B2 (en) 2009-04-13 2013-05-28 Northwestern University Peptide-based scaffolds for cartilage regeneration and methods for their use
US9493578B2 (en) 2009-09-02 2016-11-15 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
CA2787940C (en) 2010-01-27 2020-01-07 Massachusetts Institute Of Technology Engineered polypeptide agents for targeted broad spectrum influenza neutralization
TWI651096B (en) 2010-09-29 2019-02-21 美商艾澤西公司 Antibody drug conjugate (ADC) that binds to the 191P4D12 protein
KR101886029B1 (en) 2010-10-01 2018-08-07 호바 세라퓨틱스 에이피에스 Use of meteorin for the treatment of allodynia, hyperalgesia, spontaneous pain and phantom pain
US9168284B2 (en) 2010-12-14 2015-10-27 Sveinbjorn Gizurarson Biological activity of placental protein 13
CN107596346A (en) 2011-09-05 2018-01-19 霍巴治疗公司 Allodynia, hyperalgia, the treatment of spontaneous pain and phantom pain
WO2013068445A1 (en) * 2011-11-09 2013-05-16 Sanofi Diacylglycerol lipase and uses thereof
MY174248A (en) 2012-04-30 2020-04-01 Biocon Ltd Targeted/immunomodulatory fusion proteins and methods for making same
WO2013167153A1 (en) 2012-05-09 2013-11-14 Ganymed Pharmaceuticals Ag Antibodies useful in cancer diagnosis
JP2015518829A (en) 2012-05-14 2015-07-06 バイオジェン・エムエイ・インコーポレイテッドＢｉｏｇｅｎ ＭＡ Ｉｎｃ． LINGO-2 antagonist for treatment of conditions involving motor neurons
WO2013174404A1 (en) 2012-05-23 2013-11-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
CN105073776B (en) 2012-11-13 2019-04-12 拜恩科技股份公司 For treating the preparation of the Cancerous disease of expression tight junction protein
WO2014127785A1 (en) 2013-02-20 2014-08-28 Ganymed Pharmaceuticals Ag Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
US9023353B2 (en) * 2013-03-13 2015-05-05 The Board Of Trustees Of The University Of Arkansas Anti-(+)—methamphetamine monoclonal antibodies
WO2014146672A1 (en) 2013-03-18 2014-09-25 Ganymed Pharmaceuticals Ag Therapy involving antibodies against claudin 18.2 for treatment of cancer
MX2015013703A (en) 2013-03-27 2016-08-11 Cedars Sinai Medical Center Treating fibrosis and inflammation by inhibiting tl1a.
JP7019233B2 (en) 2013-07-11 2022-02-15 モデルナティエックス インコーポレイテッド Compositions and Methods of Use Containing Synthetic polynucleotides and Synthetic sgRNAs Encoding CRISPR-Related Proteins
WO2015010108A1 (en) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
RU2020106752A (en) 2013-09-25 2020-03-11 Сайтомкс Терапьютикс, Инк. SUBSTRATES OF MATRIX METALLOPROTEINASES AND OTHER DISSOLIDABLE FRAGMENTS AND METHODS FOR USING THEM
JP6558699B2 (en) 2013-10-01 2019-08-14 国立大学法人三重大学 T cell-derived vaccine containing an inter-epitope sequence that promotes antigen presentation
EP4176896A1 (en) 2014-01-31 2023-05-10 Cytomx Therapeutics Inc. Matriptase and u-plasminogen activator substrates and other cleavable moieties and methods of use thereof
WO2016112270A1 (en) 2015-01-08 2016-07-14 Biogen Ma Inc. Lingo-1 antagonists and uses for treatment of demyelinating disorders
MA41374A (en) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc MATRIX METALLOPROTEASE CLIVABLE AND SERINE PROTEASE CLIVABLE SUBSTRATES AND METHODS OF USE THEREOF
US11124766B2 (en) * 2015-06-12 2021-09-21 Emory University Growth and survival compositions for cells capable of producing antibodies and methods related thereto
CN108138198B (en) * 2015-09-04 2022-10-28 合成基因组股份有限公司 Microorganisms engineered for improved yield
KR20220153109A (en) 2016-03-17 2022-11-17 세다르스-신나이 메디칼 센터 Methods of diagnosing inflammatory bowel disease through rnaset2
WO2017172941A2 (en) * 2016-03-29 2017-10-05 Berz David Modulation of structural maintenance of chromosome-1 expression
US9611297B1 (en) 2016-08-26 2017-04-04 Thrasos Therapeutics Inc. Compositions and methods for the treatment of cast nephropathy and related conditions
US11125757B2 (en) 2017-05-26 2021-09-21 Emory University Methods of culturing and characterizing antibody secreting cells
EP3508499A1 (en) 2018-01-08 2019-07-10 iOmx Therapeutics AG Antibodies targeting, and other modulators of, an immunoglobulin gene associated with resistance against anti-tumour immune responses, and uses thereof
CN114401992A (en) 2019-07-05 2022-04-26 艾欧麦克斯治疗股份公司 Antibodies to IGSF11(VSIG3) that bind IGC2 and uses thereof
WO2021083958A1 (en) * 2019-10-29 2021-05-06 Specialites Pet Food Novel peptides inducing satiety
US20230212243A1 (en) * 2020-05-12 2023-07-06 Institut Curie Neoantigenic Epitopes Associated with SF3B1 Mutations
US20240010720A1 (en) 2020-07-06 2024-01-11 Iomx Therapeutics Ag Antibodies binding igv of igsf11 (vsig3) and uses thereof
JP2024504690A (en) * 2021-01-21 2024-02-01 エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム T cells for use in therapy
JP2024509376A (en) * 2021-02-18 2024-03-01 ベレン セラピューティクス ピー．ビー．シー． Treatment of familial heterozygous and homozygous hypercholesterolemia with cyclodextrin
WO2023225602A1 (en) * 2022-05-20 2023-11-23 Medikine, Inc. Interleukin-18 receptor binding polypeptides and uses thereof

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4446240A (en) * 1981-01-30 1984-05-01 Nerenberg Samuel T Pancreas specific protein systems
US5457038A (en) * 1988-11-10 1995-10-10 Genetics Institute, Inc. Natural killer stimulatory factor
US6080540A (en) * 1990-04-20 2000-06-27 Cold Spring Harbor Laboratory Cloning of mammalian genes in microbial organisms and methods for pharmacological screening
AU656350B2 (en) * 1990-11-26 1995-02-02 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Cell stress transcriptional factors
US5721352A (en) * 1991-02-19 1998-02-24 University Of Florida Research Foundation Entomopoxvirus expression system
US5840870A (en) * 1995-12-29 1998-11-24 Incyte Pharmaceuticals, Inc. Polynucleotides PANC1A and PANC1B associated with pancreatic cancer
WO1997007827A1 (en) * 1995-08-22 1997-03-06 Thomas Jefferson University Gab1, A Grb2 BINDING PROTEIN, AND COMPOSITIONS FOR MAKING AND METHODS OF USING THE SAME
JP3462313B2 (en) * 1995-08-24 2003-11-05 キッコーマン株式会社 Mutant uricase, mutant uricase gene, novel recombinant DNA, and method for producing mutant uricase
US5998165A (en) * 1995-12-29 1999-12-07 Incyte Pharmaceuticals, Inc. Polynucleotides encoding a protein associated with pancreatic cancer
AU721105B2 (en) * 1996-04-29 2000-06-22 Johns Hopkins University School Of Medicine, The Mammalian regulator of nonsense-mediated RNA decay
US6500934B1 (en) * 1996-07-24 2002-12-31 Michael Rush Lerner Bivalent agonists for G-protein coupled receptors
US5976834A (en) * 1997-01-09 1999-11-02 Smithkline Beecham Corporation cDNA clone HNFJD15 that encodes a novel human 7-transmembrane receptor
US5925521A (en) * 1997-03-31 1999-07-20 Incyte Pharmaceuticals, Inc. Human serine carboxypeptidase
CA2232743A1 (en) * 1997-04-02 1998-10-02 Smithkline Beecham Corporation A tnf homologue, tl5
JP2001519666A (en) * 1997-04-10 2001-10-23 ジェネティックス・インスチチュート・インコーポレーテッド Secretory expression sequence tags (sESTs)
IT1291110B1 (en) * 1997-04-15 1998-12-29 Istituto Europ Di Oncologia S INTRACELLULAR INTERACTORS AND BINDING SPECIFICITY OF THE DOMAIN EH
US5948641A (en) * 1997-05-29 1999-09-07 Incyte Pharmaceuticals, Inc. Polynucleotides encoding a metal response element binding protein
IL133315A0 (en) * 1997-06-06 2001-04-30 Regeneron Pharma Ntn-2 member of tnf ligand family
AU9484398A (en) * 1997-09-17 1999-04-05 Genentech Inc. Promotion or inhibition of angiogenesis and cardiovascularization
US5932442A (en) * 1997-09-23 1999-08-03 Incyte Pharmaceuticals, Inc. Human regulatory molecules
US5972660A (en) * 1997-10-22 1999-10-26 Incyte Pharmaceuticals, Inc. Human hydroxypyruvate reductase
DE19818598A1 (en) * 1998-04-19 1999-10-21 Metagen Gesellschaft Fuer Genomforschung Mbh New nucleic acid sequences expressed in normal pancreatic tissues, and derived polypeptides, for treatment of pancreatic cancer and identification of therapeutic agents
CN1158386C (en) * 1998-04-29 2004-07-21 吉尼西斯研究及发展有限公司 Polynucleotides isolated from skin cells and methods for their use
US6262249B1 (en) * 1998-06-23 2001-07-17 Chiron Corporation Pancreatic cancer genes
CA2296792A1 (en) * 1999-02-26 2000-08-26 Genset S.A. Expressed sequence tags and encoded human proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE GENEMBL [online] 22 December 2000 (2000-12-22), WATERSTON R.H.: "The sequence of the homo sapiens clone", XP002944903, Database accession no. AC010896 *

Also Published As

Publication number Publication date
WO2001055308A3 (en) 2002-07-04
CA2395849A1 (en) 2001-08-02
WO2001055328A2 (en) 2001-08-02
WO2001054733A8 (en) 2001-09-07
WO2001055328A8 (en) 2001-09-07
WO2001055355A1 (en) 2001-08-02
CA2392422A1 (en) 2001-08-02
WO2001055202A1 (en) 2001-08-02
AU2001241416A1 (en) 2001-08-07
CA2395403A1 (en) 2001-08-02
WO2001055207A8 (en) 2001-09-07
WO2001055321A8 (en) 2001-09-07
WO2001055206A8 (en) 2001-12-13
WO2001055315A2 (en) 2001-08-02
WO2001055350A8 (en) 2001-09-07
CA2395827A1 (en) 2001-08-02
CA2398411A1 (en) 2001-08-02
AU2001241407A1 (en) 2001-08-07
CA2392428A1 (en) 2001-08-02
WO2001055322A2 (en) 2001-08-02
WO2001055318A3 (en) 2002-07-04
CA2395724A1 (en) 2001-08-02
CA2395734A1 (en) 2001-08-02
WO2001055301A3 (en) 2009-06-04
WO2001055316A2 (en) 2001-08-02
CA2395699A1 (en) 2001-08-02
WO2001055324A3 (en) 2002-01-24
WO2001059064A2 (en) 2001-08-16
WO2001055323A8 (en) 2001-09-07
WO2001057182A2 (en) 2001-08-09
WO2001055318A2 (en) 2001-08-02
WO2001055310A2 (en) 2001-08-02
WO2001055203A1 (en) 2001-08-02
WO2001055325A8 (en) 2001-12-13
CA2395885A1 (en) 2001-08-02
CA2395666A1 (en) 2001-08-02
WO2001055311A3 (en) 2002-07-04
WO2001055163A8 (en) 2001-09-07
WO2001055312A8 (en) 2001-09-07
CA2392450A1 (en) 2001-08-16
WO2001055302A2 (en) 2001-08-02
WO2001054474A8 (en) 2001-12-20
WO2001055310A8 (en) 2001-09-07
WO2001055308A8 (en) 2001-09-07
WO2001055309A2 (en) 2001-08-02
WO2001055322A8 (en) 2001-09-07
WO2001055208A8 (en) 2001-09-07
WO2001055328A3 (en) 2002-07-04
WO2001055200A1 (en) 2001-08-02
WO2001055307A3 (en) 2002-01-10
WO2001055208A1 (en) 2001-08-02
WO2001055364A2 (en) 2001-08-02
WO2001055318A8 (en) 2001-09-07
WO2001055355A8 (en) 2001-09-07
WO2001054473A2 (en) 2001-08-02
WO2001055303A8 (en) 2001-09-07
WO2001055323A2 (en) 2001-08-02
AU2001241417A1 (en) 2001-08-07
WO2001055309A3 (en) 2002-07-18
WO2001055324A8 (en) 2001-09-07
WO2001055314A2 (en) 2001-08-02
AU4141101A (en) 2001-08-20
CA2393002A1 (en) 2001-08-02
CA2392438A1 (en) 2001-08-02
WO2001055173A8 (en) 2001-11-29
WO2001055448A8 (en) 2001-09-07
CA2397407A1 (en) 2001-08-02
WO2001055201A1 (en) 2001-08-02
WO2001055368A1 (en) 2001-08-02
AU2001241405A1 (en) 2001-08-07
WO2001055173A2 (en) 2001-08-02
WO2001055301A8 (en) 2001-09-07
WO2001055447A1 (en) 2001-08-02
WO2001055320A2 (en) 2001-08-02
WO2001055321A3 (en) 2002-07-04
WO2001055316A3 (en) 2002-04-11
CA2395654A1 (en) 2001-08-02
WO2001055303A2 (en) 2001-08-02
CA2395816A1 (en) 2001-08-02
WO2001055320A8 (en) 2001-09-07
WO2001055327A8 (en) 2001-09-07
WO2001055325A3 (en) 2002-07-04
WO2001055324A2 (en) 2001-08-02
CA2394841A1 (en) 2001-08-02
WO2001055307A2 (en) 2001-08-02
CA2395729A1 (en) 2001-08-02
CA2392757A1 (en) 2001-08-02
CA2393618A1 (en) 2001-08-02
WO2001055319A2 (en) 2001-08-02
WO2001055368A8 (en) 2001-09-07
CA2395671A1 (en) 2001-08-02
AU4313701A (en) 2001-08-14
CA2398877A1 (en) 2001-08-09
AU2001241410A1 (en) 2001-08-07
WO2001055204A1 (en) 2001-08-02
WO2001059064A3 (en) 2002-03-14
WO2001055367A1 (en) 2001-08-02
WO2001055327A2 (en) 2001-08-02
CA2392751A1 (en) 2001-08-02
WO2001055367A8 (en) 2001-12-20
WO2001057182A3 (en) 2002-03-28
CA2395178A1 (en) 2001-08-02
WO2001055316A8 (en) 2001-09-07
WO2001055310A3 (en) 2001-12-27
WO2001055387A8 (en) 2001-12-06
WO2001055203A8 (en) 2001-09-07
CA2395738A1 (en) 2002-08-02
WO2001055343A1 (en) 2001-08-02
WO2001055321A2 (en) 2001-08-02
WO2001055206A1 (en) 2001-08-02
CA2393652A1 (en) 2001-08-02
WO2001055307A8 (en) 2001-09-07
WO2001055314A8 (en) 2001-09-07
WO2001055302A8 (en) 2001-09-07
CA2395858A1 (en) 2001-08-02
WO2001055311A8 (en) 2001-09-07
WO2001055304A3 (en) 2002-07-18
WO2001055207A1 (en) 2001-08-02
WO2001055319A8 (en) 2001-09-07
CA2392398A1 (en) 2001-08-02
WO2001055350A1 (en) 2001-08-02
WO2001055327A3 (en) 2002-02-28
WO2001055312A2 (en) 2001-08-02
WO2001055301A2 (en) 2001-08-02
WO2001055315A8 (en) 2001-09-07
WO2001055163A1 (en) 2001-08-02
WO2001055315A3 (en) 2002-02-07
WO2001055319A3 (en) 2002-02-21
AU2001241406A1 (en) 2001-08-07
CA2395872A1 (en) 2001-08-02
WO2001055364A8 (en) 2001-09-07
WO2001055205A8 (en) 2001-12-13
WO2001055309A8 (en) 2001-09-07
CA2397839A1 (en) 2001-08-02
WO2001055303A3 (en) 2001-12-20
AU2001241414A1 (en) 2001-08-07
AU2001250770A1 (en) 2001-08-07
WO2001055448A1 (en) 2001-08-02
WO2001055201A8 (en) 2001-09-07
WO2001055304A8 (en) 2001-09-07
WO2001055312A3 (en) 2002-03-14
WO2001055302A3 (en) 2002-02-14
WO2001055323A3 (en) 2002-05-10
WO2001055314A3 (en) 2002-05-02
CA2395295A1 (en) 2001-08-02
WO2001055202A8 (en) 2001-09-07
AU2001241408A1 (en) 2001-08-07
AU2001241409A1 (en) 2001-08-07
WO2001055308A2 (en) 2001-08-02
CA2394039A1 (en) 2001-08-02
WO2001055447A8 (en) 2001-09-07
CA2395787A1 (en) 2001-08-02
AU2001241415A1 (en) 2001-08-07
WO2001055343A8 (en) 2001-09-07
WO2001054473A8 (en) 2001-09-07
WO2001055205A1 (en) 2001-08-02
AU2001241418A1 (en) 2001-08-07
AU2001241413A1 (en) 2001-08-07
AU2001241412A1 (en) 2001-08-07
WO2001055304A2 (en) 2001-08-02
WO2001055387A1 (en) 2001-08-02
WO2001055200A8 (en) 2001-09-07
WO2001055322A3 (en) 2002-07-04
CA2395693A1 (en) 2001-08-02
CA2393912A1 (en) 2001-08-02
WO2001055204A8 (en) 2001-09-07
WO2001055311A2 (en) 2001-08-02
WO2001054474A2 (en) 2001-08-02
CA2395398A1 (en) 2001-08-02
WO2001054733A1 (en) 2001-08-02
WO2001055320A3 (en) 2002-04-11
WO2001055325A2 (en) 2001-08-02

Similar Documents

Publication Publication Date Title
WO2001055364A3 (en) Nucleic acids, proteins, and antibodies
WO2001090304A3 (en) Nucleic acids, proteins, and antibodies
WO2001054472A3 (en) Nucleic acids, proteins, and antibodies
WO2001055306A8 (en) Nucleic acids, proteins, and antibodies
WO2001055326A8 (en) Nucleic acids, proteins, and antibodies
WO2002026930A3 (en) Nucleic acids, proteins, and antibodies
WO2001055440A8 (en) Nucleic acids, proteins, and antibodies
WO2001055168A8 (en) Nucleic acids, proteins and antibodies
WO2002072763A3 (en) Nucleic acids, proteins, and antibodies
WO2001055167A8 (en) Nucleic acids, proteins, and antibodies
WO2001055162A8 (en) Nucleic acids, proteins, and antibodies
WO2001055305A3 (en) Nucleic acids, proteins, and antibodies

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: C1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: C1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

CFP Corrected version of a pamphlet front page
CR1 Correction of entry in section i

Free format text: PAT. BUL. 31/2001 UNDER "PUBLISHED", ADD "WITH SEQUENCE LISTING PART OF DESCRIPTION PUBLISHED SEPARATELY IN ELECTRONIC FORM AND AVAILABLE UPON REQUEST FROM THE INTERNATIONAL BUREAU."

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2395827

Country of ref document: CA

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2001908612

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001908612

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001908612

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: JP

DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)