Multi-drug resistant Klebsiella pneumoniae strains circulating in hospital setting: Whole-genome sequencing and Bayesian phylogenetic analysis for outbreak investigations

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Sapienza Università Editrice, 30 nov 2022 - 154 pagine
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Carbapenems resistant Enterobacteriaceae infections are increasing worldwide representing an emerging public health problem. The application of phylogenetic and phylodynamic analyses to bacterial whole genome sequencing (WGS) data have become essential in epidemiological surveillance of MDR pathogens to discern outbreak from non-outbreak strains in both community and hospital settings.

In this study, K. pneumoniae strains circulating within different wards of university hospital were collected and WGS applied. Moreover a microbiological surveillance on duedonoscopes was performed to evaluate their reprocessing. The aim was to infer the origin and the spread of K. pneumoniae nosocomial strains and to clarify the epidemiological transmission as so as the eventual reservoir in the hospital setting supporting the epidemiological surveillance and infections control strategies.

Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.


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Eleonora Cella is currently a Postdoctoral Researcher at University of Central Florida, Orlando, Florida (US). She earned her PhD in Public Health and Infectious Diseases at the University of Rome “La Sapienza”. Her research focuses on investigating the patterns of gene flow in pathogen populations, focusing in phylogenetics and phylogeography as tools to recreate and understand the determinants of viral and bacterial outbreaks. Her experience is in the use of cutting edge genomic tools, analyzing next-generation sequencing data, and using advanced phylogenetic analytical algorithms and bioinformatics tools.

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