Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies

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Sapienza Università Editrice, 30 nov 2022 - 348 pagine
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Microtubules are essential cellular constituents of eukaryotes formed by tubulin subunits. This book is a collection of medicinal chemistry research projects that utilizes microtubules as drug targets for human diseases of global health impact. The main chapters (2 – 4) include an in-depth description of different synthetic and biological approaches to characterize the therapeutic potential of novel synthetic molecules for cancer, Alzheimer’s disease, and neglected tropical diseases. This book also includes three short chapters (5 – 7) of additional collaborative projects focused on varied drug discovery topics, including SAR studies of new lead compounds targeting carbonic anhydrase enzymes, FAAH and TRPV1, and novel bioisosteres of the carboxylic acid functional group.

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Informazioni sull'autore (2022)

Ludovica Monti was born in Rome (Italy). She obtained a Pharm.D. and a PhD from Sapienza University of Rome, where she was recognised by Sapienza as one of the best 400 graduates and awarded the “Premio Minerva alla Ricerca Scientifica” for academic excellence. She conducted half of her PhD training in the United States, at the University of Pennsylvania and University of California San Diego (UCSD). Following her PhD, Ludovica retuned to UCSD to continue her work on microtubule-targeting compounds as novel anti-parasitic agents. She is currently a Marie Curie Research Fellow at Imperial College London (UK) working on multi- omic approaches targeting DNA to fight human parasitic infections.

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