In-Vitro Toxicity Testing: Applications to Safety Evaluation

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John M. Frazier
CRC Press, 31 gen 1992 - 312 pagine
This volume focuses on the potential application of in vitro procedures to identify and quantify the toxicological risk to target organs associated with the use of commerical products and therapeutic drugs.;Revealing how the results of in vitro toxicity testing can be used in safety assessment, In Vitro Toxicity Testing: explores whether existing test methods can accomplish the necessary goals and, if not, what research is needed to make these techniques a practical reality; presents the current status of toxicity testing in the areas of hepatotoxicity, renal toxicity, ocular irritation, and many others; outlines the role of validation in technology transfer from the research laboratory to safety evaluation; examines testing strategies and regulatory acceptance and addresses common concerns about the ultimate utilization of available methods in chemical safety/hazard considerations; and analyzes the perspective of industrial and regulatory agencies on the application of in vitro toxicity testing.;Generously referenced with over 1400 literature citations, In Vitro Toxicity Testing is for academic, industrial, and regulatory toxicologists; applied, molecular, and cell biologists; pharmacologists; animal welfare activists; and graduate students in pharmacology and toxicology courses.

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Sommario

General Perspectives on In Vitro Toxicity Testing
1
In Vitro Technology Trends and Issues
13
Hepatotoxicity
45
An Evaluation of In Vitro Models for Assessing Nephrotoxicity
85
Neurotoxicity
111
Cardiovascular Toxicity
131
Ocular Irritation
149
Cutaneous Irritancy
191
Teratogenicity
205
Carcinogenicity The Use of Animal Models and ShortTerm Predictive Tests
221
Validation of In Vitro Toxicity Tests
245
Industrial Applications for In Vitro Toxicity Evaluation A Tier Testing Strategy for Product Safety Assessment
253
Regulatory Law and the Use of In Vitro Methods for the Assessment of Various Toxicities
281
Index
295
Copyright

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