Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of CancerJohn Wiley & Sons, 18 mag 2012 - 448 pagine The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate. |
Sommario
| 15 | |
Cancer Models | 31 |
Energetics of Normal Cells and Cancer Cells | 47 |
Respiratory Dysfunction in Cancer Cells | 73 |
Proteomic Abnormalities in Tumor Cell Mitochondria | 79 |
Cardiolipin and Abnormal Energy Metabolism in Tumor Cells | 85 |
Complicating Influence of the In Vitro Growth Environment on Cardiolipin | 92 |
Cancer Cell Heat Production and Uncoupled Mitochondria | 98 |
Summary | 168 |
Respiratory Insufficiency the Retrograde Response and the Origin | 177 |
Abnormalities in Growth Control Telomerase Activity Apoptosis | 207 |
Metastasis | 215 |
Mitochondrial Respiratory Dysfunction and the Extrachromosomal | 253 |
Nothing in Cancer Biology Makes Sense Except in the Light | 261 |
Cancer Treatment Strategies | 277 |
Metabolic Management of Cancer | 291 |
The Warburg Dispute | 107 |
Is Respiration Normal in Cancer Cells? | 119 |
Is Mitochondrial Glutamine Fermentation a Missing Link in | 133 |
Genes Respiration Viruses and Cancer | 145 |
Germline Mutations Damaged Respiration and Cancer | 154 |
Revisiting the Oncogene Theory | 160 |
Patient Implementation of Metabolic Therapies for Cancer | 355 |
Cancer Prevention | 375 |
Case Studies and Personal Experiences in Using the Ketogenic Diet | 387 |
Conclusions | 405 |
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Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of ... Thomas Seyfried Anteprima limitata - 2012 |
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