Xenobiotic Metabolism and Disposition: The Design of Studies on Novel CompoundsCRC Press, 28 feb 1989 - 232 pagine This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such stud-ies. |
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Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds Harry P.A. Illing Anteprima limitata - 2019 |
Xenobiotic Metabolism and Disposition: The Design of Studies on Novel Compounds Harry P.A. Illing Anteprima limitata - 2019 |
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absorbed absorption acid activity administration animals assay autoradiography balance studies benzo(a)pyrene biliary excretion binding bioavailability Biochem blood flow buffer calculated cannula carbon cell chemical chromatography clearance clinical collected column compound concentration curve cytochrome P450 determined dosage regimen dose level drug development drug metabolism effects elimination enterohepatic circulation enzyme ethanol example exponential extraction feces Figure film glucuronide halflife hepatic homogenates HPLC induced intestinal investigated ionization isolated kidney kinetic labeled lipid liver material measured membrane metabolism studies metabolite profiling metabolites method microsomal molecular molecule normally obtained oral perfusion pharmacokinetic Pharmacol pharmacological phase phenobarbitone plasma levels plate polar portal vein possible preparation procedure propranolol protein radioactivity radiolabeled renal result route sample scintillation sections solvent species spectra spectroscopy substrate suitable technique therapeutic tissue toxicity Toxicol toxicology tritium urine usually vitro vivo volatile volume of distribution whole body autoradiography
Brani popolari
Pagina 220 - Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants, Cancer Res., 38 (1978) 4486.
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