Introduction to Enzyme and Coenzyme Chemistry

Copertina anteriore
John Wiley & Sons, 29 mag 2012 - 304 pagine

Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry.

The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function.

This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

 

Pagine selezionate

Sommario

Preface
5
6
1
8
1
Contents
72
Enzymatic AdditionElimination Reactions 170
Enzymatic Transformations of Amino Acids 185
Isomerases 200
Glycoproteins
NonEnzymatic Biological Catalysis 228
1
15
47

From Jack Beans to Designer Genes
Enzymatic CarbonCarbon Bond Formation 139
Copyright

Altre edizioni - Visualizza tutto

Introduction to Enzyme and Coenzyme Chemistry
T. D. H. Bugg
Anteprima limitata - 2012
Introduction to Enzyme and Coenzyme Chemistry
T. D. H. Bugg
Anteprima limitata - 2012

Parole e frasi comuni

189mm Enzymatic 189mm Introduction 9:4 Printer acetyl CoA active site acyl aldolase amino acid aspartate atom attack binding biological biosynthesis carbanion carbon Carbon–Carbon Bond Formation carboxylate catalyses catalytic antibodies Chem chiral chorismate cleavage CO2H Coenzyme Chemistry cofactor containing covalent crystal structure cysteine decarboxylation dehydratase dehydrogenase deprotonation dioxygenases electron enamine EnzS enzymatic enzymatic reaction enzyme active Enzyme and Coenzyme enzyme catalysis ester example FADH2 flavin histidine hydrogen hydrolysis hydroxyl hydroxyl group inactivated Incubation inhibitor intermediate Introduction to Enzyme involved isomerase JWST182-Bugg April 25 ketone kinetic isotope effect lysine mechanism methyl group molecule mutase NAD+ NADH NADPH nucleophilic O3PO OH OH OH oxidised oxygen PDB file phosphate proteases protein proton pyrophosphate racemase radical redox potential reductase residues SCoA serine shown in Figure sidechain specific stabilisation stereochemistry stereospecifically substituents substrate synthase thioester transition Trim vitamin

Informazioni sull'autore (2012)

Professor Timothy Bugg, Department of Chemistry, University of Warwick, UK
Professor Bugg is Professor of Biological Chemistry at the University of Warwick. Following his PhD studies with Dr C. Abell at the University of Cambridge he spent two years as a SERC/NATO postdoctoral research fellow in the laboratory of Professor CT Walsh at Harvard Medical School. In 1991 he began his academic career as a lecturer in organic chemistry at the University of Southampton, before moving to Warwick in 1999. His research interests are in the study of enzyme mechanisms, principally enzymes involved in the bacterial degradation of aromatic compounds, and enzymes involved in bacterial peptidoglycan biosynthesis. He has published approximately 100 journal publications since 1988, is the author of "An Introduction to Enzyme and Coenzyme Chemistry" (2 editions), and a contributor to "Comprehensive Natural Products Chemistry", and "Encyclopaedia of Chemical Biology" (for which he is on the Advisory Board).

Informazioni bibliografiche

TitoloIntroduction to Enzyme and Coenzyme Chemistry
AutoreT. D. H. Bugg
Edizione3
EditoreJohn Wiley & Sons, 2012
ISBN1118348990, 9781118348994
Lunghezza304 pagine
  
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