Tumor Suppressor Genes, Volume 1

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Wafik S. El-Deiry
Springer Science & Business Media, 2003 - 657 pagine
Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, leading physician scientists and academic researchers review all the known tumor suppressor genes, explain how they work, and describe how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to isolate and characterize novel tumor suppressor genes and their targets. The companion volume of this set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, demonstrates how best to explore the cell biology and biochemical function of such genes, and their encoded proteins, to study their physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer. Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.
 

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Indice

Growth Control by the Retinoblastoma Gene Family
3
Identification of DNA Binding of Tumor Suppressor Genes
10
Flow Cytometric Analysis of Cell Cycle Control
17
The APC Tumor Suppressor Pathway
21
The Tissue Microenvironment as an Epigenetic Tumor Modifier
24
Blocking Survivin to Kill Cancer Cells
34
Hereditary Breast and Ovarian Cancer Genes
41
Hereditary Colon Cancer Genes
59
The Regulation of Tumor Suppressor Genes by Oncogenes
269
Determination of Cancer Allelotype
295
Epidemiological Approaches to the Identification
309
Characterization of Translocations in Human Cancer
327
Positional Approaches to Cancer Genetics
339
Hybrid Capture of Putative Tumor Suppressor Genes
365
Approaches to Proteomic Analysis of Human Tumors
375
Representational Difference Analysis of Gene Expression
385

Patched Hedgehog and Skin Cancer
85
TP53 hChk2 and the LiFraumeni Syndrome
117
Genetic Alterations in Esophageal Cancer
131
PTEN and Cancer
147
VHL and Kidney Cancer
167
p16INK4A and Familial Melanoma
185
Progression Model of Prostate Cancer
211
Wilms Tumor as a Model for Cancer Biology
239
Inadequate Caretaker Gene Function
249
Antisense Libraries to Isolate Tumor Suppressor Genes
399
Genetic Suppressor Elements in the Characterization
413
Crosslinking Subtractive Hybridization
437
Suppression Subtractive Hybridization for Identification
453
SAGE as a Strategy to Isolate CancerRelated Genes
463
Differential Display Techniques to Identify Tumor Suppressor
481
Detection of Mismatch Repair Gene Expression
491
Index
501
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