RNA Motifs and Regulatory ElementsSpringer Science & Business Media, 2002 - 233 pagine RNA Motifs and Regulatory Elements is the new edition of the successful book, "Regulatory RNA". It alerts the reader to the importance of regulatory RNA elements for the many different areas of cellular life.The computational and experimental methods and tools to search for new interesting regulatory RNA structures are explained and compared. The knowledge on regulatory RNA structures and elements already available is concisely summarized as well as catalogued. In addition, interesting RNA elements are analyzed in detail regarding their dynamics, regulation, and as a dominant topic of current resarch in molecular biology, including areas such as RNA mediated regulation of gene-expression, DNA/RNA chip data, and ribozymes, splicing, or telomerases in aging. Medical implications are also covered. Future progress and research are finally outlined. |
Sommario
Introduction | 1 |
13 Examining Regulatory RNA Elements | 3 |
14 Regulation of Gene Expression | 7 |
15 Catalytic Active RNA | 8 |
16 Combination of RNA and Proteins | 9 |
18 Context Specificity of RNA Within the Cell | 10 |
Instances of Functional RNA | 13 |
22 The Different Types of RNA and Their Regulatory Elements | 15 |
43 Example Searches | 92 |
44 Motif Specific Searches for RNA Elements | 93 |
45 GeneralPurpose Search Programs | 98 |
46 Evaluation of the Search Result | 102 |
Functional RNA Interactions | 111 |
53 Catalytic RNA | 114 |
54 RNA Motif Evolution | 117 |
55 RNAProtein Interactions | 118 |
23 RNA Motifs Involved in Splicing | 20 |
24 RNA Editing | 22 |
25 Posttranscriptional Regulatory Signals in mRNA | 23 |
26 Further Regulatory RNAs | 26 |
28 Correction of Missing Stop Codons by 10SaRNA | 27 |
210 Regulation of Prokaryotic Operons | 28 |
211 Cytoplasmic RNA Motifs | 29 |
212 Ribozymes and Their Motifs | 30 |
214 Other RNA Species | 32 |
215 A Catalogue of Regulatory RNA Motifs | 33 |
216 RNA Motifs in RNA Viridae | 40 |
217 Protein Motifs Pointing to Interacting RNA Structures | 42 |
218 Modified Nucleotides | 43 |
from Known Instances to New Ones | 44 |
Experimental Identification of New Functional RNA | 69 |
32 Typical Challenges | 70 |
33 Cellular Regulation | 72 |
34 Confirmation of RNA Functionality | 77 |
ComputerBased and Theoretical Identification of Regulatory RNA | 85 |
42 Carrying Out an RNA Motif Search | 86 |
56 Designing Interactions | 123 |
57 Medical Implications | 126 |
58 Perspectives | 135 |
Areas of Research on RNA Motifs and Regulatory Elements | 139 |
63 The Splicing of Messenger RNA | 140 |
64 TransSplicing | 144 |
65 RNA Editing | 147 |
66 Ribosomal RNA Processing Steps | 154 |
67 Nuclear RNA Transport | 158 |
68 Regulatory Motifs in mRNA | 159 |
69 Posttranscriptional Gene Silencing and RNA Interference | 166 |
610 Catalytic RNA and Motifs | 168 |
611 Viral RNAs | 170 |
Outlook | 181 |
72 Established Areas of Research | 182 |
73 Conclusion | 184 |
FigureAcknowledgement | 185 |
References | 187 |
| 225 | |
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Acids Res activity base pairing binding protein catalytic RNA Cech cellular Chap chromosome cleavage complex consensus conserved cytoplasmic Dandekar database different RNA domain Drosophila elegans EMBO encoded eukaryotic examples exon factor function further GCN4 gene expression genetic genome group II intron hairpin hammerhead Hentze human identified inhibition initiation instance interactions involved IRES iron-responsive element loop mammalian mediated methylation mitochondria modification Mol Biol Mol Cell Biol mRNA mutations Nucleic Acids nucleotides oligonucleotides open reading frame pathway poly(A polyadenylation polymerase pre-mRNA precursor pseudoknot reactions receptor recognition region regulation regulatory elements regulatory motifs regulatory RNA motifs ribonucleoprotein ribosomal RNA ribozyme RNA editing RNA elements RNA molecule RNA sequences RNA structure RNA-binding RNAse rRNA secondary structure small nuclear small nucleolar RNAs snRNA snRNP specific spliceosome splicing stability stem stem-loop synthesis Tollervey trans-splicing transcription Translational control tRNA U2 snRNA upstream viral virus vitro vivo yeast