Advances in Virus Research

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Academic Press, 17 ott 2000 - 628 pagine
Virology is the branch of microbiology that deals with viruses and viral infections. The overall goal of virus research is understand the action of various viruses and develop vaccines or techniques that are effective at preventing or treating the diseases caused by them. Viruses that affect humans range in severity from the rhinoviruses that cause the "common cold" to the human immune deficiency (HIV) virus that causes AIDS.By their very nature, viruses are highly contagious and therefore affect millions of people, plants, and animals. This field continues to have new discoveries that are important to researchers and clinicians in the field.

Dall'interno del libro

Sommario

Basic Studies and Applications
1
Chapter 2 SV40 Large T Antigen Functions in DNA Replication and Transformation
75
Past and Prospects
135
Chapter 4 Mechanism of Genome Transcription in Segmented dsRNA Viruses
185
Chapter 5 Structures and Mechanisms in Flavivirus Fusion
231
Viroids Containing Hammerhead Ribozymes
271
Chapter 7 Virus Resistance Mediated by Ribosome Inactivating Proteins
325
Biology and Molecular Biology
357
Chapter 11 EpsteinBarr Virus Vectors for Gene Therapy
453
A New Herpesvirus Vector Approach
463
Chapter 13 Adenovirus Vectors for Human Gene Therapy
479
Chapter 14 AdenoAssociated Virus VectorMediated Gene Transfer to Somatic Cells in the Central Nervous System
507
Chapter 15 Production of Recombinant AdenoAssociated Virus
529
Chapter 16 Retroviral Vectors
545
Chapter 17 Alphavirus Expression Vectors
565
Chapter 18 Transfectant Influenza Viruses as Antigen Delivery Vectors
579

Virus Vectors for Gene Therapy
401
Chapter 9 ReplicationCompetent Herpes Simplex Viral Vectors for Cancer Therapy
409
Chapter 10 Herpes Simplex Virus Type 1Based Amplicon Vector Systems
425
Chapter 19 Lentiviral Vectors
599
Index
611
Copyright

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Pagina 63 - First human trial of a DNA-based vaccine for treatment of human immunodeficiency virus type 1 infection; safety and host response. J Infect Dis 1998; 178:92-100.
Pagina 49 - Akbari, O., Panjwani, N., Garcia, S., Tascon, R., Lowrie, D., and Stockinger, B. (1999) DNA vaccination: Transfection and activation of dendritic cells as key events for immunity. J. Exp. Med.
Pagina 119 - WS, Harper, JW, O'Connor, PM, Velculescu, VE, Canman, CE, Jackman, J., Pietenpol, JA, Burrell, M., Hill, DE, Wang, Y, Wilman, KG, Mercer, WE, Kastan, MB, Kohn, KW, Elledge, SJ, Kinzler, KW, and Vogelstein, B.
Pagina 57 - TA (1998). DNA immunization against herpes simplex virus: Enhanced efficacy using a Sindbis virus-based vector.
Pagina 65 - Porgador, A., Irvine, KR, Iwasaki, A., Barber, BH, Restifo, NP, and Germain, RN (1998) Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization. J. Exp. Med. 188, 1075-1082.
Pagina 521 - N., et al. (1991) Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J.
Pagina 521 - Kotin, RM, Siniscalco, M., Samulski, RJ, Zhu, XD, Hunter, L., Laughlin, CA, McLaughlin, S., Muzyczka, N., Rocchi, M., and Berns, KI (1990).
Pagina 60 - Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus.

Informazioni sull'autore (2000)

Professor Karl Maramorosch works at Rutgers University, New Brunswick, NJ, USA.

Frederick A. Murphy, DVM, PhD, is professor, Department of Pathology, University of Texas Medical Branch (UTMB), Galveston. He holds a BS and DVM from Cornell University and a PhD from the University of California, Davis (UC Davis). Formerly he was dean and distinguished professor, School of Veterinary Medicine, and distinguished professor, School of Medicine, UC Davis. Before that he served as director of the National Center for Infectious Diseases, and director of the Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta. He is a member of the Institute of Medicine of the U.S. National Academy of Sciences and is a member of the German National Academy of Sciences and the Belgian Royal Academy of Medicine. He holds an honorary Doctor of Medicine and Surgery from the University of Turku, Finland; an honorary Doctor of Science from the University of Guelph, Canada; an honorary Doctor of Veterinary Medicine from the University of London, United Kingdom; an honorary Doctor of Science from University College Dublin, Ireland; the Presidential Rank Award of the U.S. Government; the PennVet World Leadership Award from the University of Pennsylvania, and the Distinguished Microbiologist Award from the American College of Veterinary Microbiologists. At UTMB, he is a member of the Institute for Human Infections and Immunity, Center for Biodefense and Emerging Infectious Diseases, Galveston National Laboratory, and McLaughlin Endowment for Infection and Immunity. His professional interests include the pathology and epidemiology of highly pathogenic viruses/viral diseases: rabies and the rabies-like viruses, arboviruses, hemorrhagic fever viruses, and other neurotropic viruses. He has been a leader in advancing the concepts of “new and emerging infectious diseases and “new and emerging zoonoses and “the threat posed by bioterrorism. Most recently, he has been working on Internet resources on the history of virology: “The Foundations of Virology at http://www.utmb.edu/virusimages/.

Informazioni bibliografiche