NMR of Paramagnetic Molecules: Applications to Metallobiomolecules and Models

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Elsevier, 15 set 2016 - 508 pagine
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NMR of Paramagnetic Molecules: Applications to Metallobiomolecules and Models, Second Edition is a self-contained, comprehensive reference for chemists, physicists, and life scientists whose research involves analyzing paramagnetic compounds. Since the previous edition of this book was published, there have been many advancements in the field of paramagnetic NMR spectroscopy. This completely updated and expanded edition contains the latest fundamental theory and methods for mastery of this analytical technique. Users will learn how to interpret the NMR spectra of paramagnetic molecules, improve experimental techniques, and strengthen their understanding of the underlying theory and applications.

  • Reflects all advances in the field in a completely updated new edition
  • Presents new material on self-orientation residual dipolar couplings, solid state NMR, dynamic nuclear polarization, and paramagnetic restraints for structure calculations
  • Includes information relevant to paramagnetic molecules, metallobiomolecules, paramagnetic compounds, and paramagnetic NMR spectroscopy
  • Presents specific examples of paramagnetic inorganic species and experimental techniques for structure characterization
 

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Indice

Chapter 1 Introduction
1
Chapter 2 The hyperfine shift
25
residual dipolar couplings
61
Chapter 4 Relaxation
77
Chapter 5 High resolution solidstate NMR in paramagnetic molecules
127
Chapter 6 Chemical exchange chemical equilibria and dynamics
151
shift and relaxation
175
shift and relaxation
255
Appendix I NMR properties of nuclei
457
Appendix II Dipolar coupling between two spins
461
Appendix III Derivation of the equations for contact shift and relaxation in a simple case
463
Appendix IV Derivation of the pseudocontact shift equations in different forms
467
Appendix V Relaxation by dipolar interaction between two spins
471
Curies law
477
Appendix VII Derivation of the equations related to NOE
479
Appendix VIII Magnetically coupled dimers in the hightemperature limit
483

Chapter 9 Paramagnetic restraints for structure and dynamics of biomolecules
277
Chapter 10 Relaxometry and contrast agents for MRI
313
Chapter 11 Magnetic coupled systems
347
Chapter 12 Hints on experimental techniques
383
Appendix IX Reference tables
485
Index
489
Back cover
497
Copyright

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Informazioni sull'autore (2016)

Ivano Bertini, born on December 6, 1940 in Pisa, Italy, obtained the Italian degree of Doctor of Chemistry at the University of Florence in 1964 and became Full Professor of General and Inorganic Chemistry in 1975 at the University of Florence. A member of the Academia Europaea and the Italian Accademia dei Lincei, he received the Laurea Honoris Causa from the University of Stockholm, Ioannina and Siena. In 1999, he founded the Magnetic Resonance Center (CERM), a major NMR infrastructure in the Life Sciences. His main research interests included advancements in nuclear magnetic resonance spectroscopy, the expression and preparation of metalloproteins, their structural characterization, and the investigation of their interactions, with an emphasis on understanding cellular processes at the molecular level. He published over 650 research articles and solved more than 150 protein structures. He passed away on July 7, 2012.

Claudio Luchinat, born in Florence, Italy, on February 15, 1952, obtained his doctor in chemistry cum laude at the University of Florence. He was a postdoctor and researcher at the University of Florence, and Full Professor of Chemistry at the University of Bologna (1986-1996) and Florence (1996-). He is a recipient of the “Raffaello Nasini gold medal award for inorganic chemistry of the Italian Chemical Society, 1989; Federchimica Award “For an Intelligent Future , 1994; European Medal for Biological Inorganic Chemistry, 1996; and “GDRM gold medal for magnetic resonance , 2001. His research interests include development of NMR-based structural methodologies in solution and in the solid state, theory of electron and nuclear relaxation, NMR of paramagnetic species, relaxometry, contrast agents, bioinorganic chemistry, metabolomics and NMR-based analytical methods. He is the author of more than 500 publications and of four books. His h-index is above 70 and his papers have been cited more than 20,000 times.

Giacomo Parigi, born in Borgo San Lorenzo, Italy, on September 17, 1967, graduated in Physics at the University of Florence (1992) and obtained his Ph.D. in chemistry at the University of Florence, Italy. He is Associate Professor of Chemistry since 2006 at the University of Florence. His research interests are mainly oriented to the study of NMR effects related to paramagnetism for the structural and dynamic characterization of biomolecules, to the analysis of the relaxometric profiles of paramagnetic systems and biomolecules, and to nuclear and electron relaxation.

Enrico Ravera, born in Arezzo, Italy, on April 1, 1986, obtained a B. Sc. in Chemistry in 2008, M. Sc. in Chemistry cum laude in 2009 and PhD in Chemistry in 2013. He is currently a researcher at the Interuniversity Consortium of Magnetic Resonance of Metallo-Proteins (CIRMMP).

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