PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 479
... GABA - trans- aminase ( GABA - T ) , which is inhibited by vigabatrine , a compound used to treat epilepsy ( Ch . 36 ) . GABA - ergic neurons have an active GABA uptake system , and it is this , rather than GABA - T , which removes the GABA ...
... GABA - trans- aminase ( GABA - T ) , which is inhibited by vigabatrine , a compound used to treat epilepsy ( Ch . 36 ) . GABA - ergic neurons have an active GABA uptake system , and it is this , rather than GABA - T , which removes the GABA ...
Pagina 481
... GABA and glycine GABA is the main inhibitory transmitter in the brain . It is present fairly uniformly throughout the brain ; there is very little in peripheral tissues . GABA is formed from glutamate , by the action of GAD ( glutamic ...
... GABA and glycine GABA is the main inhibitory transmitter in the brain . It is present fairly uniformly throughout the brain ; there is very little in peripheral tissues . GABA is formed from glutamate , by the action of GAD ( glutamic ...
Pagina 532
... GABA , by facilitating the opening of GABA - activated chloride channels ( Fig . 33.2 ) . As described in Chapter 29 , benzodiazepines bind specifically to a regulatory site the receptor , distinct from the GABA binding site , and act ...
... GABA , by facilitating the opening of GABA - activated chloride channels ( Fig . 33.2 ) . As described in Chapter 29 , benzodiazepines bind specifically to a regulatory site the receptor , distinct from the GABA binding site , and act ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular