PharmacologyThe aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 110
acetylcholine was some 100 000 times more active than choline in lowering the
rabbit ' s blood pressure . Although Hunt ' s studies suggested that acetylcholine
was present in tissues , its physiological function was not apparent at that time ...
acetylcholine was some 100 000 times more active than choline in lowering the
rabbit ' s blood pressure . Although Hunt ' s studies suggested that acetylcholine
was present in tissues , its physiological function was not apparent at that time ...
Pagina 112
H. P. Rang, M. Maureen Dale, J. M. Ritter. Fig . 7 . 1 Dale ' s experiment showing
that acetylcholine produces two kinds of effect on the cat ' s blood pressure .
Arterial pressure was recorded with a mercury manometer from a spinal cat . A
ACh ...
H. P. Rang, M. Maureen Dale, J. M. Ritter. Fig . 7 . 1 Dale ' s experiment showing
that acetylcholine produces two kinds of effect on the cat ' s blood pressure .
Arterial pressure was recorded with a mercury manometer from a spinal cat . A
ACh ...
Pagina 115
Cholinergic vesicles accumulate acetylcholine actively , by means of a specific
transport protein , a serpentine structure comprising 12 transmembrane helical
regions , belonging to the general family of amine transporters which are ...
Cholinergic vesicles accumulate acetylcholine actively , by means of a specific
transport protein , a serpentine structure comprising 12 transmembrane helical
regions , belonging to the general family of amine transporters which are ...
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Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine acid action activity agents agonists animals antagonists associated binding block blood body bone brain calcium cardiac cause cells central changes channels Chapter chemical clinical compounds concentration decrease dependence depression discussed disease dopamine dose drugs effects enzyme evidence example excretion factor function GABA gene given glucose glutamate growth half-life heart hormone human important increase inhibition inhibitors injection insulin interaction involved known less liver mainly mechanisms mediators membrane molecules myocardial infarction Nature nerve nervous system neurons noradrenaline normal occur oestrogens orally pain pathway patients peptides pharmacological phase plasma potential pressure prevent produce protein reactions receptors reduced regulation release response result risk role secretion selective shown similar smooth muscle specific stimulation structure studies substances synthesis Table terminals therapeutic therapy thyroid tissues transmission transmitter transport treat treatment trials types unwanted effects various vascular
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Informazioni bibliografiche
| Titolo | Pharmacology Churchill Livingstone |
| Autori | H. P. Rang, M. Maureen Dale, J. M. Ritter |
| Edizione | 4, illustrata, ristampa |
| Editore | Churchill Livingstone, 1999 |
| Provenienza dell'originale | la University of Michigan |
| Digitalizzato | 18 ago 2008 |
| ISBN | 0443059748, 9780443059742 |
| Lunghezza | 830 pagine |
| Esporta citazione | BiBTeX EndNote RefMan |