PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 251
... action potential of an idealised cardiac muscle cell is shown in Figure 14.1A , and is divided into five phases : Phase 0 , rapid depolarisation , occurs when the mem- brane potential reaches the critical firing threshold ( about -60 mV ) ...
... action potential of an idealised cardiac muscle cell is shown in Figure 14.1A , and is divided into five phases : Phase 0 , rapid depolarisation , occurs when the mem- brane potential reaches the critical firing threshold ( about -60 mV ) ...
Pagina 262
... action potential . The net result of catecholamine action is to elevate and steepen the ventricular function curve ( Fig . 14.5 ) . The increase in heart rate results from an increased slope of the pace- maker potential ( Figs 14.1 and ...
... action potential . The net result of catecholamine action is to elevate and steepen the ventricular function curve ( Fig . 14.5 ) . The increase in heart rate results from an increased slope of the pace- maker potential ( Figs 14.1 and ...
Pagina 268
... action . The special feature that defines them as class III drugs is that they sub- stantially prolong the cardiac action potential . The mechanism of this effect is still not fully understood , but involves blocking some of the ...
... action . The special feature that defines them as class III drugs is that they sub- stantially prolong the cardiac action potential . The mechanism of this effect is still not fully understood , but involves blocking some of the ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular