PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 48
... activity of antipsychotic drugs , there being no animal model ' equivalent ( either naturally occurring or experimentally produced ) of schizophrenia . Assessment of a new compound is usually based on a profile of activity in a range of ...
... activity of antipsychotic drugs , there being no animal model ' equivalent ( either naturally occurring or experimentally produced ) of schizophrenia . Assessment of a new compound is usually based on a profile of activity in a range of ...
Pagina 254
... activity Under pathological conditions , pacemaker activity can arise in other parts of the heart than the SA node and conducting tissues . The main predisposing factors are : ⚫ catecholamine action ⚫ partial depolarisation , such as ...
... activity Under pathological conditions , pacemaker activity can arise in other parts of the heart than the SA node and conducting tissues . The main predisposing factors are : ⚫ catecholamine action ⚫ partial depolarisation , such as ...
Pagina 530
... activity was recognised in a routine screening procedure , and benzodiazepines quite soon became the most widely prescribed drugs in the pharmacopoeia . CHEMISTRY AND STRUCTURE - ACTIVITY RELATIONSHIPS The basic chemical structure of ...
... activity was recognised in a routine screening procedure , and benzodiazepines quite soon became the most widely prescribed drugs in the pharmacopoeia . CHEMISTRY AND STRUCTURE - ACTIVITY RELATIONSHIPS The basic chemical structure of ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular