PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
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Pagina 530
... Benzodiazepines : the most important class , used for treating both anxiety states and insomnia . 5 - HT1A - receptor agonists : recently introduced ... Benzodiazepines decrease the time taken 530 THE CENTRAL NERVOUS SYSTEM Benzodiazepines.
... Benzodiazepines : the most important class , used for treating both anxiety states and insomnia . 5 - HT1A - receptor agonists : recently introduced ... Benzodiazepines decrease the time taken 530 THE CENTRAL NERVOUS SYSTEM Benzodiazepines.
Pagina 531
... Benzodiazepines decrease the time taken to get to sleep , and increase the total duration of sleep , though the latter effect occurs only in subjects who normally sleep for less than about 6 hours each night . Both effects tend to ...
... Benzodiazepines decrease the time taken to get to sleep , and increase the total duration of sleep , though the latter effect occurs only in subjects who normally sleep for less than about 6 hours each night . Both effects tend to ...
Pagina 536
... benzodiazepines , as does dependence , which is their main drawback . They share these properties with other hypnotics and sedatives . Tolerance is less marked than it is with barbiturates , which produce pharmacokinetic tolerance ...
... benzodiazepines , as does dependence , which is their main drawback . They share these properties with other hypnotics and sedatives . Tolerance is less marked than it is with barbiturates , which produce pharmacokinetic tolerance ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular