PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 73
... BODY BODY FLUID COMPARTMENTS Body water is distributed into four main compartments as shown in Figure 4.9 . The total body water as a percentage of body weight varies from 50-70 % , being rather less in women than in men . Extracellular ...
... BODY BODY FLUID COMPARTMENTS Body water is distributed into four main compartments as shown in Figure 4.9 . The total body water as a percentage of body weight varies from 50-70 % , being rather less in women than in men . Extracellular ...
Pagina 75
... body fluid compartments ( l / kg body weight ) 0.05-0.1 0.1-0.2 0.2-0.4 0.4-0.7 Drug elimination and pharmacokinetics COOH Drug ( DH ) NADPH. Volume ( l / kg body weight ) 0.05 Compartment Va Plasma Heparin Insulin Warfarin 0.2 ...
... body fluid compartments ( l / kg body weight ) 0.05-0.1 0.1-0.2 0.2-0.4 0.4-0.7 Drug elimination and pharmacokinetics COOH Drug ( DH ) NADPH. Volume ( l / kg body weight ) 0.05 Compartment Va Plasma Heparin Insulin Warfarin 0.2 ...
Pagina 399
... body weight in the hypothalamus ? 403 Obesity as a health problem 404 The pathophysiology of obesity 404 - Obesity ... body had a homeostatic system for controlling body fat and that the CNS was involved . At the beginning of this ...
... body weight in the hypothalamus ? 403 Obesity as a health problem 404 The pathophysiology of obesity 404 - Obesity ... body had a homeostatic system for controlling body fat and that the CNS was involved . At the beginning of this ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular