PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
Risultati 1-3 di 48
Pagina 38
... bradykinin , which causes excitation of sensory neurons ( see Ch . 37 ) causes a transient increase in [ Ca2 + ] ; from the resting value of about 150 nmol / l . When calcium is removed from the extracellular solution , the bradykinin ...
... bradykinin , which causes excitation of sensory neurons ( see Ch . 37 ) causes a transient increase in [ Ca2 + ] ; from the resting value of about 150 nmol / l . When calcium is removed from the extracellular solution , the bradykinin ...
Pagina 221
... BRADYKININ Bradykinin and the closely related peptide kallidin are vasoactive peptides formed by the action of enzymes on protein substrates termed kininogens . The two peptides are virtually identical ( see Fig . 12.13 ) , kallidin ...
... BRADYKININ Bradykinin and the closely related peptide kallidin are vasoactive peptides formed by the action of enzymes on protein substrates termed kininogens . The two peptides are virtually identical ( see Fig . 12.13 ) , kallidin ...
Pagina 222
... bradykinin and some bradykinin antagonists . The sites of proteolytic cleavage for formation of kallidin and bradykinin by kallikrein from HMW - kininogen are shown in the upper half of the figure ; the sites of cleavage for bradykinin ...
... bradykinin and some bradykinin antagonists . The sites of proteolytic cleavage for formation of kallidin and bradykinin by kallikrein from HMW - kininogen are shown in the upper half of the figure ; the sites of cleavage for bradykinin ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
46 sezioni non visualizzate
Altre edizioni - Visualizza tutto
Parole e frasi comuni
acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular