PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
Risultati 1-3 di 91
Pagina 250
... Cardiac rate and rhythm 250 Cardiac contraction 255 Myocardial oxygen consumption and coronary blood flow 257 Atrial natriuretic peptide ( ANP ) and B type natriuretic peptide 261 Drugs that affect cardiac function 261 Autonomic ...
... Cardiac rate and rhythm 250 Cardiac contraction 255 Myocardial oxygen consumption and coronary blood flow 257 Atrial natriuretic peptide ( ANP ) and B type natriuretic peptide 261 Drugs that affect cardiac function 261 Autonomic ...
Pagina 257
... cardiac output as before . As with increased pre - load , cardiac work and cardiac oxygen consumption both increase . Normally the filling pressure is only a few centimetres of water above zero , on the steep part of the ventricular ...
... cardiac output as before . As with increased pre - load , cardiac work and cardiac oxygen consumption both increase . Normally the filling pressure is only a few centimetres of water above zero , on the steep part of the ventricular ...
Pagina 263
... cardiac slowing and reduced automaticity ⚫ decreased force of contraction ( mainly in atria ) ⚫ inhibition of AV ... cardiac efficiency ( in relation to oxygen consumption ) . B. - adrenoceptors act by increasing cAMP formation , which ...
... cardiac slowing and reduced automaticity ⚫ decreased force of contraction ( mainly in atria ) ⚫ inhibition of AV ... cardiac efficiency ( in relation to oxygen consumption ) . B. - adrenoceptors act by increasing cAMP formation , which ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular