PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 128
... cause 100 % block of the tetanic tension of the indirectly stimulated adductor pollicis muscle . Recovery of tension was then followed as a function of time . ( From : Payne J P , Hughes R 1981 Br J Anaesth 53:45 ) by cleavage at one of ...
... cause 100 % block of the tetanic tension of the indirectly stimulated adductor pollicis muscle . Recovery of tension was then followed as a function of time . ( From : Payne J P , Hughes R 1981 Br J Anaesth 53:45 ) by cleavage at one of ...
Pagina 762
... cause carcinogenesis and teratogenesis . common cause of death following self - poisoning in the UK in 1989 ) . An outline of the initial reactions in which this drug is involved is given in Chapter 13 , page 236 and Figure 13.1 ...
... cause carcinogenesis and teratogenesis . common cause of death following self - poisoning in the UK in 1989 ) . An outline of the initial reactions in which this drug is involved is given in Chapter 13 , page 236 and Figure 13.1 ...
Pagina 764
... cause heavy proteinuria ( Ch . 15 ) . This is due to glomerular injury and is also caused by other drugs that ... cause hepatotoxicity can also cause toxic damage to the kidney , most commonly by pro- ducing necrosis of renal tubular ...
... cause heavy proteinuria ( Ch . 15 ) . This is due to glomerular injury and is also caused by other drugs that ... cause hepatotoxicity can also cause toxic damage to the kidney , most commonly by pro- ducing necrosis of renal tubular ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular