PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 488
... Dopamine receptors D1 D1 type D5 Distribution Cortex Functional role Arousal , mood ++ Limbic system Emotion , stereotypic behaviour +++ Basal ganglia Hypothalamus Motor control ++ Autonomic and endocrine control ++ Pituitary gland ...
... Dopamine receptors D1 D1 type D5 Distribution Cortex Functional role Arousal , mood ++ Limbic system Emotion , stereotypic behaviour +++ Basal ganglia Hypothalamus Motor control ++ Autonomic and endocrine control ++ Pituitary gland ...
Pagina 489
... dopamine antag- onists , and by destruction of dopamine - containing cell bodies in the midbrain , but not by drugs that inhibit the noradrenergic system . These amphetamine - induced motor disturbances in rats probably reflect ...
... dopamine antag- onists , and by destruction of dopamine - containing cell bodies in the midbrain , but not by drugs that inhibit the noradrenergic system . These amphetamine - induced motor disturbances in rats probably reflect ...
Pagina 509
... dopamine transport system , and thus acts selectively on dop- aminergic neurons ; it inhibits mitochondrial oxidation reactions , producing oxidative stress ( see above ; Tipton & Singer 1993 ) . MPTP appears to be selective in ...
... dopamine transport system , and thus acts selectively on dop- aminergic neurons ; it inhibits mitochondrial oxidation reactions , producing oxidative stress ( see above ; Tipton & Singer 1993 ) . MPTP appears to be selective in ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular