PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 81
... example , one variant ( CYP2D6 ) leads to poor and extensive hydroxylation of debrisoquine . Environmental factors ( Ch . 48 ) are also important . Enzyme inhibitors and inducers are present in the diet and environment ( e.g. grapefruit ...
... example , one variant ( CYP2D6 ) leads to poor and extensive hydroxylation of debrisoquine . Environmental factors ( Ch . 48 ) are also important . Enzyme inhibitors and inducers are present in the diet and environment ( e.g. grapefruit ...
Pagina 185
... example , at a tumour antigen ) , or a peptide ( for example bombesin or somatostatin , which bind to receptors on tumour cells ) linked to a toxin ( such as ricin or diphtheria toxin ) to kill the cells ( see Ch . 42 ) . Another ...
... example , at a tumour antigen ) , or a peptide ( for example bombesin or somatostatin , which bind to receptors on tumour cells ) linked to a toxin ( such as ricin or diphtheria toxin ) to kill the cells ( see Ch . 42 ) . Another ...
Pagina 317
... example non- steroidal anti - inflammatory drugs , moxalactam , carbenicillin . Aspirin increases the risk of bleeding if given during warfarin therapy , although this com- bination can be used safely with careful monitoring . • Drugs ...
... example non- steroidal anti - inflammatory drugs , moxalactam , carbenicillin . Aspirin increases the risk of bleeding if given during warfarin therapy , although this com- bination can be used safely with careful monitoring . • Drugs ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular