PharmacologyThe aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 312
The components ( ' factors ' ) are present in blood as inactive precursors (
Rzymogens ' ) of proteolytic enzymes and ... Activation of a small amount of one
factor catalyses the formation of larger amounts of the next factor which catalyses
the ...
The components ( ' factors ' ) are present in blood as inactive precursors (
Rzymogens ' ) of proteolytic enzymes and ... Activation of a small amount of one
factor catalyses the formation of larger amounts of the next factor which catalyses
the ...
Pagina 313
by secreting coagulation factors , including factor Va and fibrinogen . Coagulation
is sustained by further generation of factor Xa by IXa - VIIIa - calcium -
phospholipid complex . This is needed because the tissue factor - VIIa complex is
rapidly ...
by secreting coagulation factors , including factor Va and fibrinogen . Coagulation
is sustained by further generation of factor Xa by IXa - VIIIa - calcium -
phospholipid complex . This is needed because the tissue factor - VIIa complex is
rapidly ...
Pagina 314
Activated protein C , helped by its cofactor protein S , inactivates factors Va and
VIIa . This is known to be physiologically important , because a naturally
occurring mutation of the gene coding for factor V ( “ factor V Leiden ' ) that
confers ...
Activated protein C , helped by its cofactor protein S , inactivates factors Va and
VIIa . This is known to be physiologically important , because a naturally
occurring mutation of the gene coding for factor V ( “ factor V Leiden ' ) that
confers ...
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Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine acid action activity agents agonists animals antagonists associated binding block blood body bone brain calcium cardiac cause cells central changes channels Chapter chemical clinical compounds concentration decrease dependence depression discussed disease dopamine dose drugs effects enzyme evidence example excretion factor function GABA gene given glucose glutamate growth half-life heart hormone human important increase inhibition inhibitors injection insulin interaction involved known less liver mainly mechanisms mediators membrane molecules myocardial infarction Nature nerve nervous system neurons noradrenaline normal occur oestrogens orally pain pathway patients peptides pharmacological phase plasma potential pressure prevent produce protein reactions receptors reduced regulation release response result risk role secretion selective shown similar smooth muscle specific stimulation structure studies substances synthesis Table terminals therapeutic therapy thyroid tissues transmission transmitter transport treat treatment trials types unwanted effects various vascular
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Informazioni bibliografiche
| Titolo | Pharmacology Churchill Livingstone |
| Autori | H. P. Rang, M. Maureen Dale, J. M. Ritter |
| Edizione | 4, illustrata, ristampa |
| Editore | Churchill Livingstone, 1999 |
| Provenienza dell'originale | la University of Michigan |
| Digitalizzato | 18 ago 2008 |
| ISBN | 0443059748, 9780443059742 |
| Lunghezza | 830 pagine |
| Esporta citazione | BiBTeX EndNote RefMan |