PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 66
... gastrointestinal tract . P - glycoprotein ( the drug transporter responsible for multidrug resistance in neoplastic cells , p . 680 ) has recently been found in renal tubular brush border mem- branes , in bile canaliculi , in astrocyte ...
... gastrointestinal tract . P - glycoprotein ( the drug transporter responsible for multidrug resistance in neoplastic cells , p . 680 ) has recently been found in renal tubular brush border mem- branes , in bile canaliculi , in astrocyte ...
Pagina 233
... gastrointestinal events are the commonest un- wanted effects of the NSAIDs , the relative risk being on average three times that in the population of non- NSAID users . Common gastrointestinal side - effects are dyspepsia , diarrhoea ...
... gastrointestinal events are the commonest un- wanted effects of the NSAIDs , the relative risk being on average three times that in the population of non- NSAID users . Common gastrointestinal side - effects are dyspepsia , diarrhoea ...
Pagina 370
... gastrointestinal tract 370 Gastric secretion 371 -The regulation of acid secretion by parietal cells 371 Drugs used to inhibit or neutralise gastric ... gastrointestinal system The innervation and the hormones of the gastrointestinal tract.
... gastrointestinal tract 370 Gastric secretion 371 -The regulation of acid secretion by parietal cells 371 Drugs used to inhibit or neutralise gastric ... gastrointestinal system The innervation and the hormones of the gastrointestinal tract.
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular