PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
Risultati 1-3 di 56
Pagina 470
... glutamate receptors 474 Glutamate antagonists 477 Gamma - aminobutyric acid ( GABA ) 478 Synthesis , storage and function 478 GABA receptors - structure and pharmacology 479 Drugs acting on GABA receptors 479 Glycine 480 In this chapter ...
... glutamate receptors 474 Glutamate antagonists 477 Gamma - aminobutyric acid ( GABA ) 478 Synthesis , storage and function 478 GABA receptors - structure and pharmacology 479 Drugs acting on GABA receptors 479 Glycine 480 In this chapter ...
Pagina 473
... glutamate binding site , in contrast to most amine receptors in which the agonist binding site is buried amongst the transmembrane helices ( Ch . 2 ) . Binding studies show that glutamate receptors are most abundant in the cortex ...
... glutamate binding site , in contrast to most amine receptors in which the agonist binding site is buried amongst the transmembrane helices ( Ch . 2 ) . Binding studies show that glutamate receptors are most abundant in the cortex ...
Pagina 501
... glutamate applied to neurons in culture kills the cells , and the finding in the 1970s that glutamate given orally produces neurodegeneration in vivo caused considerable alarm , because of the widespread use of glutamate as a ' taste ...
... glutamate applied to neurons in culture kills the cells , and the finding in the 1970s that glutamate given orally produces neurodegeneration in vivo caused considerable alarm , because of the widespread use of glutamate as a ' taste ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
46 sezioni non visualizzate
Altre edizioni - Visualizza tutto
Parole e frasi comuni
acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular