PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
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Pagina 411
... GROWTH HORMONE - RELEASING FACTOR ( GHRF ; SOMATORELIN ) GHRF is a peptide with 40-44 amino acid residues , active at a concentration of 10-15 mol / l . An analogue , sermorelin , has been introduced as a diagnostic test for growth ...
... GROWTH HORMONE - RELEASING FACTOR ( GHRF ; SOMATORELIN ) GHRF is a peptide with 40-44 amino acid residues , active at a concentration of 10-15 mol / l . An analogue , sermorelin , has been introduced as a diagnostic test for growth ...
Pagina 412
... GROWTH HORMONE ( GH ; SOMATOTROPIN ) Growth hormone is derived from the somatotroph cells and is found in the anterior pituitary in larger quantities than any other pituitary hormone . Secretion of growth hormone is high in the newborn ...
... GROWTH HORMONE ( GH ; SOMATOTROPIN ) Growth hormone is derived from the somatotroph cells and is found in the anterior pituitary in larger quantities than any other pituitary hormone . Secretion of growth hormone is high in the newborn ...
Pagina 764
... growth regulation . It usually requires more than one . mutation in a cell to initiate the changes that result in malignancy , mutations in proto - oncogenes ( which regu- late cell growth ) and tumour suppressor genes ( which code for ...
... growth regulation . It usually requires more than one . mutation in a cell to initiate the changes that result in malignancy , mutations in proto - oncogenes ( which regu- late cell growth ) and tumour suppressor genes ( which code for ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular