PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 211
... histamine receptors * Table 12.1b Details of some antagonist drugs used to define. for the existence of a third type of histamine receptor— the H3 - receptor - was produced by Arrang et al . ( 1983 ) . Synthesis and storage of histamine ...
... histamine receptors * Table 12.1b Details of some antagonist drugs used to define. for the existence of a third type of histamine receptor— the H3 - receptor - was produced by Arrang et al . ( 1983 ) . Synthesis and storage of histamine ...
Pagina 212
... Histamine stimulates the secretion of gastric acid by action on H2 - receptors . In clinical terms , this is the most important action of histamine , since it is implicated in the pathogenesis of peptic ulcer . It is considered in ...
... Histamine stimulates the secretion of gastric acid by action on H2 - receptors . In clinical terms , this is the most important action of histamine , since it is implicated in the pathogenesis of peptic ulcer . It is considered in ...
Pagina 372
... histamine - secreting cell ; Hist histamine ; ACh = acetylcholine ; MR = muscarinic receptor ; H2R histamine H2 - receptor ; = GR = gastrin receptor ; PGR = prostaglandin E2 ( PGE2 ) receptor ; AA = arachidonic acid ; NSAIDs = non ...
... histamine - secreting cell ; Hist histamine ; ACh = acetylcholine ; MR = muscarinic receptor ; H2R histamine H2 - receptor ; = GR = gastrin receptor ; PGR = prostaglandin E2 ( PGE2 ) receptor ; AA = arachidonic acid ; NSAIDs = non ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular