PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 37
... intracellular calcium ) . The role of IP4 , which is formed from IP3 and other inositol phosphates , is unclear , but it may facilitate calcium entry through the plasma membrane . IP3 is inactivated by dephosphorylation to inositol ...
... intracellular calcium ) . The role of IP4 , which is formed from IP3 and other inositol phosphates , is unclear , but it may facilitate calcium entry through the plasma membrane . IP3 is inactivated by dephosphorylation to inositol ...
Pagina 38
... intracellular calcium , resulting from the intracellular production of IP3 . The difference between this and the larger response when calcium is present extracellularly is believed to represent calcium entry through receptor - operated ...
... intracellular calcium , resulting from the intracellular production of IP3 . The difference between this and the larger response when calcium is present extracellularly is believed to represent calcium entry through receptor - operated ...
Pagina 41
... intracellular ( effector ) domains , with about 400-700 residues in each . In the case of the insulin receptor , most of the extracellular domain consists of a separate polypeptide chain which is linked by disul- phide bonds to the ...
... intracellular ( effector ) domains , with about 400-700 residues in each . In the case of the insulin receptor , most of the extracellular domain consists of a separate polypeptide chain which is linked by disul- phide bonds to the ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular