PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 43
... involved in this cascade , leading to activation of the cascade in the absence of the growth factor signal ( see Ch . 41 ) . ( For more details , see reviews by Avruch et al . 1994 , Marshall 1996. ) A second pathway , the Jak / Stat ...
... involved in this cascade , leading to activation of the cascade in the absence of the growth factor signal ( see Ch . 41 ) . ( For more details , see reviews by Avruch et al . 1994 , Marshall 1996. ) A second pathway , the Jak / Stat ...
Pagina 224
... involved in the induction of the immune response described above and outlined in Figure 12.3 ⚫ those involved in the effector phase of the immune / inflammatory response , which we will consider now . The effector phase cytokines ...
... involved in the induction of the immune response described above and outlined in Figure 12.3 ⚫ those involved in the effector phase of the immune / inflammatory response , which we will consider now . The effector phase cytokines ...
Pagina 422
... involved in dimer formation . ( iii ) Hinge domain : is involved in nuclear localisation , transcription and dimer formation . ( iv ) Steroid - binding domain : binds steroid and is involved in nuclear localisation and dimer formation ...
... involved in dimer formation . ( iii ) Hinge domain : is involved in nuclear localisation , transcription and dimer formation . ( iv ) Steroid - binding domain : binds steroid and is involved in nuclear localisation and dimer formation ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular