PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
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Pagina 22
... channels Some ion channels ( known as ligand - gated ion channels ) are directly linked to a receptor , and open only when the receptor is occupied by an agonist , However , many other types of ion channel also serve as targets for drug ...
... channels Some ion channels ( known as ligand - gated ion channels ) are directly linked to a receptor , and open only when the receptor is occupied by an agonist , However , many other types of ion channel also serve as targets for drug ...
Pagina 29
... ion channels . In the steady state , the rate of opening balances the rate of closing , but from moment to moment the number of open channels will show random fluctuations about the mean . By measuring the amplitude of these ...
... ion channels . In the steady state , the rate of opening balances the rate of closing , but from moment to moment the number of open channels will show random fluctuations about the mean . By measuring the amplitude of these ...
Pagina 30
... ion channels in the small patch of membrane under the pipette tip . Towards the end of the record two channels can be seen to open simultaneously . The conductance and mean lifetime of these channels agrees well with indirect estimates ...
... ion channels in the small patch of membrane under the pipette tip . Towards the end of the record two channels can be seen to open simultaneously . The conductance and mean lifetime of these channels agrees well with indirect estimates ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular