PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 179
... MEDIATOR The soluble peptide mediators in the body , which are secreted by cells , and act on surface receptors of other cells , can be very broadly divided into ( a ) neuroendocrine mediators ( discussed further in this chapter ) , ( b ) ...
... MEDIATOR The soluble peptide mediators in the body , which are secreted by cells , and act on surface receptors of other cells , can be very broadly divided into ( a ) neuroendocrine mediators ( discussed further in this chapter ) , ( b ) ...
Pagina 200
... Mediators are generated both from plasma and from cells during the vascular events , and these mediators in turn modify and regulate the vascular and cellular events . VASCULAR EVENTS AND THE MEDIATORS DERIVED FROM PLASMA The vascular ...
... Mediators are generated both from plasma and from cells during the vascular events , and these mediators in turn modify and regulate the vascular and cellular events . VASCULAR EVENTS AND THE MEDIATORS DERIVED FROM PLASMA The vascular ...
Pagina 339
... mediators There is evidence that airway function is influenced by neuronal mediators other than acetylcholine and nor- adrenaline ; these are referred to as NANC mediators ( see Ch . 6 , p . 104 ) . The inhibitory NANC mediator - the ...
... mediators There is evidence that airway function is influenced by neuronal mediators other than acetylcholine and nor- adrenaline ; these are referred to as NANC mediators ( see Ch . 6 , p . 104 ) . The inhibitory NANC mediator - the ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular