PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 78
... metabolism and excretion . Excretion involves the loss of chemically unchanged drug , metabolism the conversion of one chemical entity to another . The main routes by which drugs and their metabolites leave the body are : ⚫ the kidneys ...
... metabolism and excretion . Excretion involves the loss of chemically unchanged drug , metabolism the conversion of one chemical entity to another . The main routes by which drugs and their metabolites leave the body are : ⚫ the kidneys ...
Pagina 387
... metabolism Insulin influences glucose metabolism in all tissues , espe- cially the liver where it inhibits glycogenolysis ( glycogen breakdown ) and gluconeogenesis ( synthesis of glucose from non - carbohydrate sources ) while ...
... metabolism Insulin influences glucose metabolism in all tissues , espe- cially the liver where it inhibits glycogenolysis ( glycogen breakdown ) and gluconeogenesis ( synthesis of glucose from non - carbohydrate sources ) while ...
Pagina 812
... metabolism , 218 receptors , 218 synthesis , 217-18 , 219 Leuprorelin , 446 Levamisole , 657 , 743 Levodopa ( L - dopa ) , 509-10 intestinal absorption , 69 in parkinsonism , 509-10 unwanted effects , 510-11 Levonorgestrol in combined ...
... metabolism , 218 receptors , 218 synthesis , 217-18 , 219 Leuprorelin , 446 Levamisole , 657 , 743 Levodopa ( L - dopa ) , 509-10 intestinal absorption , 69 in parkinsonism , 509-10 unwanted effects , 510-11 Levonorgestrol in combined ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular