PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
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Pagina xiii
... MOLECULES TO CELLS One of the basic tenets of pharmacology is that drug molecules must exert some chemical influence on one or more constituents of cells in order to produce a pharma- cological response . In other words , drug molecules ...
... MOLECULES TO CELLS One of the basic tenets of pharmacology is that drug molecules must exert some chemical influence on one or more constituents of cells in order to produce a pharma- cological response . In other words , drug molecules ...
Pagina 61
... as filters , retaining large molecules and letting smaller ones through . The cut off of molecular size is not exact : water transfers rapidly whereas molecules of 80 61 Absorption and distribution of drugs Translocation of drug molecules.
... as filters , retaining large molecules and letting smaller ones through . The cut off of molecular size is not exact : water transfers rapidly whereas molecules of 80 61 Absorption and distribution of drugs Translocation of drug molecules.
Pagina 62
... molecules of 80 000-100 000 daltons molecular weight transfer very slowly . In some organs , especially the central nervous system and the placenta , there are tight junctions between the cells , and penetration by drug molecules ...
... molecules of 80 000-100 000 daltons molecular weight transfer very slowly . In some organs , especially the central nervous system and the placenta , there are tight junctions between the cells , and penetration by drug molecules ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular