PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 97
... nerve as filaments that run to the paravertebral chain of sympathetic ganglia , which lies bilaterally on either side of the spinal column . Each preganglionic nerve branches , and makes synaptic contact with ganglion cells in several ...
... nerve as filaments that run to the paravertebral chain of sympathetic ganglia , which lies bilaterally on either side of the spinal column . Each preganglionic nerve branches , and makes synaptic contact with ganglion cells in several ...
Pagina 101
... nerve section . Pharmacological block of ganglionic trans- mission , for example , if sustained for a few days , causes some degree of supersensitivity of the target organs , and long - term blockade of postsynaptic receptors also ...
... nerve section . Pharmacological block of ganglionic trans- mission , for example , if sustained for a few days , causes some degree of supersensitivity of the target organs , and long - term blockade of postsynaptic receptors also ...
Pagina 144
... nerve activity in many smooth muscle tissues . NORADRENALINE RELEASE The processes linking the arrival of a nerve impulse at a noradrenergic nerve terminal to the release of nor- adrenaline are basically the same as those at other ...
... nerve activity in many smooth muscle tissues . NORADRENALINE RELEASE The processes linking the arrival of a nerve impulse at a noradrenergic nerve terminal to the release of nor- adrenaline are basically the same as those at other ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular