PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
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Pagina 100
... neurons are cholinergic , ganglionic transmission occurs via nicotinic ACh receptors ( though excitatory muscarinic ACh receptors are also present on postganglionic cells ) . • Postganglionic parasympathetic neurons are cholinergic ...
... neurons are cholinergic , ganglionic transmission occurs via nicotinic ACh receptors ( though excitatory muscarinic ACh receptors are also present on postganglionic cells ) . • Postganglionic parasympathetic neurons are cholinergic ...
Pagina 509
... neurons ; it inhibits mitochondrial oxidation reactions , producing oxidative stress ( see above ; Tipton & Singer 1993 ) . MPTP appears to be selective in destroying nigrostriatal neurons , and does not affect dopaminergic neurons ...
... neurons ; it inhibits mitochondrial oxidation reactions , producing oxidative stress ( see above ; Tipton & Singer 1993 ) . MPTP appears to be selective in destroying nigrostriatal neurons , and does not affect dopaminergic neurons ...
Pagina 584
... neuron Periphery Fig . 37.5 The descending control system , showing the main sites of action of opioids on pain transmission . Opioids excite neurons in the periaqueductal grey matter ( PAG ) and in the nucleus reticularis ...
... neuron Periphery Fig . 37.5 The descending control system , showing the main sites of action of opioids on pain transmission . Opioids excite neurons in the periaqueductal grey matter ( PAG ) and in the nucleus reticularis ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular