PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Risultati 1-3 di 88
Pagina 143
... Noradrenaline Phenylethanolamine N - methyl transferase OH но CH – CH , NH – CH , но Fig . 8.2 Biosynthesis of catecholamines Adrenaline terminals in company with noradrenaline ; this presumably represents enzyme that is in a soluble ...
... Noradrenaline Phenylethanolamine N - methyl transferase OH но CH – CH , NH – CH , но Fig . 8.2 Biosynthesis of catecholamines Adrenaline terminals in company with noradrenaline ; this presumably represents enzyme that is in a soluble ...
Pagina 144
... noradrenaline , and it is generally assumed that a reversible complex , depending partly on the opposite charges on the mole- cules of noradrenaline and ATP , is formed within the vesicle . This would serve both to reduce the osmolarity ...
... noradrenaline , and it is generally assumed that a reversible complex , depending partly on the opposite charges on the mole- cules of noradrenaline and ATP , is formed within the vesicle . This would serve both to reduce the osmolarity ...
Pagina 157
... noradrenaline from sympathetic nerve terminals . It has little effect on the adrenal medulla , and none on nerve terminals that release transmitters other than noradrenaline . Drugs very similar to it include bretylium , bethanidine ...
... noradrenaline from sympathetic nerve terminals . It has little effect on the adrenal medulla , and none on nerve terminals that release transmitters other than noradrenaline . Drugs very similar to it include bretylium , bethanidine ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular