PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 146
... occurs in both neuronal and non- neuronal tissues . It acts on both the catecholamines themselves and the deaminated products , such as DOMA , that are produced by the action of MAO . The main final metabolite of adrenaline and ...
... occurs in both neuronal and non- neuronal tissues . It acts on both the catecholamines themselves and the deaminated products , such as DOMA , that are produced by the action of MAO . The main final metabolite of adrenaline and ...
Pagina 180
... occurs within the transport and secretory vesicles , and the products are released from the cell by exocytosis . Constitutive secretion ( e.g. secretion of plasma proteins , clotting factors , etc. by liver cells ) occurs continuously ...
... occurs within the transport and secretory vesicles , and the products are released from the cell by exocytosis . Constitutive secretion ( e.g. secretion of plasma proteins , clotting factors , etc. by liver cells ) occurs continuously ...
Pagina 209
... occurs in auto- immune * disease . It is when this happens that it becomes necessary to use anti - inflammatory or immuno- suppressive drugs . Unwanted immune responses are termed allergic or hypersensitivity reactions and have been ...
... occurs in auto- immune * disease . It is when this happens that it becomes necessary to use anti - inflammatory or immuno- suppressive drugs . Unwanted immune responses are termed allergic or hypersensitivity reactions and have been ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular