PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 188
... oxide and its control 188 Degradation and carriage of nitric oxide 191 Effects of nitric oxide 191 Therapeutic use of nitric oxide and nitric oxide donors 193 Inhibition of nitric oxide 193 Clinical conditions in which nitric oxide may ...
... oxide and its control 188 Degradation and carriage of nitric oxide 191 Effects of nitric oxide 191 Therapeutic use of nitric oxide and nitric oxide donors 193 Inhibition of nitric oxide 193 Clinical conditions in which nitric oxide may ...
Pagina 197
... oxide synthase . Science 261 : 1445–1448 Liu J , Garcia - Cardena G , Sessa W C 1996 Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide : implications for caveolae ...
... oxide synthase . Science 261 : 1445–1448 Liu J , Garcia - Cardena G , Sessa W C 1996 Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide : implications for caveolae ...
Pagina 523
... OXIDE Nitrous oxide is an odourless gas with many advanta- geous features for anaesthesia , and is in widespread use . It is rapid in action , because of its low blood : gas partition coefficient ( Table 32.1 ) , and is also an ...
... OXIDE Nitrous oxide is an odourless gas with many advanta- geous features for anaesthesia , and is in widespread use . It is rapid in action , because of its low blood : gas partition coefficient ( Table 32.1 ) , and is also an ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular