PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 312
... pathway ) Contact ( e.g. with glass ) Ca2 + Vit K reductase ). last step in a complex enzyme cascade . The components ... pathway is especially important in controlling blood coagulation in the body and can accurately be called the in ...
... pathway ) Contact ( e.g. with glass ) Ca2 + Vit K reductase ). last step in a complex enzyme cascade . The components ... pathway is especially important in controlling blood coagulation in the body and can accurately be called the in ...
Pagina 313
... pathway commences when factor XII ( ' Hageman factor ' ) adheres to a negatively charged surface , and converges with the in vivo pathway at the stage of factor X activation ( see Fig . 17.2 ) . The proximal part of this pathway is not ...
... pathway commences when factor XII ( ' Hageman factor ' ) adheres to a negatively charged surface , and converges with the in vivo pathway at the stage of factor X activation ( see Fig . 17.2 ) . The proximal part of this pathway is not ...
Pagina 616
... PATHWAYS An important reward pathway involved in drug depen- dence is the mesolimbic dopaminergic pathway ( see Ch . 30 ) running , via the medial forebrain bundle , from the ventral midbrain ( A10 cell group ) to the nucleus accumbens ...
... PATHWAYS An important reward pathway involved in drug depen- dence is the mesolimbic dopaminergic pathway ( see Ch . 30 ) running , via the medial forebrain bundle , from the ventral midbrain ( A10 cell group ) to the nucleus accumbens ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular