PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 155
... patients , the use of B - receptor antagonists increases the likelihood of exercise - induced hypoglycaemia because the normal adrenaline - induced release of glucose from the liver is diminished . Clinical use The main uses of B ...
... patients , the use of B - receptor antagonists increases the likelihood of exercise - induced hypoglycaemia because the normal adrenaline - induced release of glucose from the liver is diminished . Clinical use The main uses of B ...
Pagina 270
... patients in whom other drugs are ineffective or contraindicated , because of its adverse effects , which include torsades de pointes , and thyroid and pulmonary diseases . ( Racemic ) sotalol ( i.e. the form available for prescription ) ...
... patients in whom other drugs are ineffective or contraindicated , because of its adverse effects , which include torsades de pointes , and thyroid and pulmonary diseases . ( Racemic ) sotalol ( i.e. the form available for prescription ) ...
Pagina 714
... patients . Pharmacokinetic aspects Aciclovir can be given orally , intravenously or topically . When it is given ... patients , intravenously in immunocompromised patients to treat herpes simplex infections ( genital herpes ...
... patients . Pharmacokinetic aspects Aciclovir can be given orally , intravenously or topically . When it is given ... patients , intravenously in immunocompromised patients to treat herpes simplex infections ( genital herpes ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular