PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 74
... Plasma 10 5 1.0 0.5- CSF ( meningitis ) CSF ( normal ) 0.1 0 1 2 Time ( hours ) 3 4 56 Fig . 4.10 Plasma and CSF concentrations of an antibiotic ( thienamycin ) following an intravenous dose ( 25 mg / kg ) . In normal rabbits , no drug ...
... Plasma 10 5 1.0 0.5- CSF ( meningitis ) CSF ( normal ) 0.1 0 1 2 Time ( hours ) 3 4 56 Fig . 4.10 Plasma and CSF concentrations of an antibiotic ( thienamycin ) following an intravenous dose ( 25 mg / kg ) . In normal rabbits , no drug ...
Pagina 89
... plasma concentration is reduced and delayed by slow absorption , and the duration of action somewhat increased . B Measurements of plasma aminophylline concentration in man following equal oral and intravenous doses . ( Data from ...
... plasma concentration is reduced and delayed by slow absorption , and the duration of action somewhat increased . B Measurements of plasma aminophylline concentration in man following equal oral and intravenous doses . ( Data from ...
Pagina 92
... plasma concentration . These problems are well recog- nised for drugs such as phenytoin , an anticonvulsant whose plasma concentration needs to be closely con- trolled to achieve an optimal clinical effect ( see Ch . 36 ) ...
... plasma concentration . These problems are well recog- nised for drugs such as phenytoin , an anticonvulsant whose plasma concentration needs to be closely con- trolled to achieve an optimal clinical effect ( see Ch . 36 ) ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular