PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 110
... pressure owing to their content of adrenaline . In 1900 Reid Hunt found that after adrenaline had been removed from such extracts , they produced a fall in blood pressure instead of a rise . He attributed the fall to their content of ...
... pressure owing to their content of adrenaline . In 1900 Reid Hunt found that after adrenaline had been removed from such extracts , they produced a fall in blood pressure instead of a rise . He attributed the fall to their content of ...
Pagina 257
... pressure . ( Redrawn from : Sarnoff SJ et al . 1960 Circ Res 8 : 1108 ) and mean arterial pressure . Cardiac work and cardiac oxygen consumption both increase . Peripheral arteriolar vasoconstriction increases after- load . End ...
... pressure . ( Redrawn from : Sarnoff SJ et al . 1960 Circ Res 8 : 1108 ) and mean arterial pressure . Cardiac work and cardiac oxygen consumption both increase . Peripheral arteriolar vasoconstriction increases after- load . End ...
Pagina 258
... pressures ( Fig . 14.6 ) . If diastolic aortic pres- sure falls or diastolic ventricular pressure increases , then perfusion pressure falls and so ( unless other control mechanisms can compensate ) does coronary blood flow . Stenosis of ...
... pressures ( Fig . 14.6 ) . If diastolic aortic pres- sure falls or diastolic ventricular pressure increases , then perfusion pressure falls and so ( unless other control mechanisms can compensate ) does coronary blood flow . Stenosis of ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular