PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
Risultati 1-3 di 73
Pagina 45
... result in resistance to these hormones . Conditions in which receptor mutations result in permanently switched - on effector mechanisms in the absence of agonist have also been described ( see Lefkowitz 1993 ) . One of these involves ...
... result in resistance to these hormones . Conditions in which receptor mutations result in permanently switched - on effector mechanisms in the absence of agonist have also been described ( see Lefkowitz 1993 ) . One of these involves ...
Pagina 55
... result . The results of a trial cannot , by their nature , be absolutely conclusive . This is because it is based on a sample of patients and there is always a chance that the sample was atypical of the population from which it came ...
... result . The results of a trial cannot , by their nature , be absolutely conclusive . This is because it is based on a sample of patients and there is always a chance that the sample was atypical of the population from which it came ...
Pagina 135
... result is an initial excitation , which can result in convulsions , followed by depression , which can cause unconsciousness and respiratory failure . These central effects result mainly from the activation of muscarinic receptors , and ...
... result is an initial excitation , which can result in convulsions , followed by depression , which can cause unconsciousness and respiratory failure . These central effects result mainly from the activation of muscarinic receptors , and ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular