PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
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Pagina 114
... shown acting postsynaptically on a nicotinic receptor controlling a cation channel ( e.g. at the neuromuscular or ganglionic synapse ) . There is evidence that a presynaptic nicotine receptor ( not shown ) can act to facilitate ACh ...
... shown acting postsynaptically on a nicotinic receptor controlling a cation channel ( e.g. at the neuromuscular or ganglionic synapse ) . There is evidence that a presynaptic nicotine receptor ( not shown ) can act to facilitate ACh ...
Pagina 174
... shown that ATP is released , in a calcium - dependent fashion , on nerve stimulation , and that exogenous ATP in general mimics the effects of nerve stimulation in various pre- parations . Furthermore , suramin , a drug recently shown ...
... shown that ATP is released , in a calcium - dependent fashion , on nerve stimulation , and that exogenous ATP in general mimics the effects of nerve stimulation in various pre- parations . Furthermore , suramin , a drug recently shown ...
Pagina 334
... shown as ' B12 ' and as ' methyl B12 ' , but the enzyme is not shown . ) Methionine is important in the donation of formate ( shown by dashed line ) for the conversion of tetrahydrofolate ( FH ) to formyl tetrahydrofolate ( formyl - FH ) ...
... shown as ' B12 ' and as ' methyl B12 ' , but the enzyme is not shown . ) Methionine is important in the donation of formate ( shown by dashed line ) for the conversion of tetrahydrofolate ( FH ) to formyl tetrahydrofolate ( formyl - FH ) ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular