PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
Risultati 1-3 di 78
Pagina 295
... side - effects . The preferred regimes have changed progressively as better drugs have become available . Centrally acting α - agonists ( e.g. clonidine ) , or methyldopa ( which is metabolised to α - methylnoradrenaline , an α ...
... side - effects . The preferred regimes have changed progressively as better drugs have become available . Centrally acting α - agonists ( e.g. clonidine ) , or methyldopa ( which is metabolised to α - methylnoradrenaline , an α ...
Pagina 556
... side - effects , which are discussed below . Mechanism of action 1 As discussed above , the main effect of TCA is to block the uptake of amines by nerve terminals , by competition for the binding site of the carrier protein ( Ch . 8 ) ...
... side - effects , which are discussed below . Mechanism of action 1 As discussed above , the main effect of TCA is to block the uptake of amines by nerve terminals , by competition for the binding site of the carrier protein ( Ch . 8 ) ...
Pagina 577
... side - effects : drowsiness , behavioural and mood changes • Lamotrigine - Acts by inhibiting sodium channels - Broad therapeutic profile — Main side - effects are hypersensitivity reactions ( especially skin rashes ) • Felbamate ...
... side - effects : drowsiness , behavioural and mood changes • Lamotrigine - Acts by inhibiting sodium channels - Broad therapeutic profile — Main side - effects are hypersensitivity reactions ( especially skin rashes ) • Felbamate ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular