PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Risultati 1-3 di 95
Pagina 149
... Smooth muscle All types of smooth muscle , except that of the gastro- intestinal tract , contract in response to stimulation of a1- adrenoceptors . a - receptor stimulation causes a rise in the free intracellular calcium concentration ...
... Smooth muscle All types of smooth muscle , except that of the gastro- intestinal tract , contract in response to stimulation of a1- adrenoceptors . a - receptor stimulation causes a rise in the free intracellular calcium concentration ...
Pagina 279
... smooth muscle tone , followed by the actions of vaso- constrictor and vasodilator drugs and clinical uses of vasodilators in the treatment of hypertension , shock and cardiac failure . The use of vasoactive drugs in ... smooth muscle tone.
... smooth muscle tone , followed by the actions of vaso- constrictor and vasodilator drugs and clinical uses of vasodilators in the treatment of hypertension , shock and cardiac failure . The use of vasoactive drugs in ... smooth muscle tone.
Pagina 281
... smooth muscle explain the otherwise puzzling fact that mediators that increase cytoplasmic CAMP relax smooth muscle but increase cardiac con- traction . The importance of IP3 - mediated Ca2 + release in smooth muscle is also relevant to ...
... smooth muscle explain the otherwise puzzling fact that mediators that increase cytoplasmic CAMP relax smooth muscle but increase cardiac con- traction . The importance of IP3 - mediated Ca2 + release in smooth muscle is also relevant to ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular