PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
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Pagina 354
... sodium into the cell is coupled to that of other solutes by various symport systems . * Glucose enters the cell with sodium by such a symport process , the co - transport being driven by the electro- chemical gradient for sodium across ...
... sodium into the cell is coupled to that of other solutes by various symport systems . * Glucose enters the cell with sodium by such a symport process , the co - transport being driven by the electro- chemical gradient for sodium across ...
Pagina 358
... sodium is re - absorbed , because the influx of sodium into the cell through sodium channels down the electrochemical gradient created by the basolateral sodium pump results in depolarisation of the luminal but not the basolateral ...
... sodium is re - absorbed , because the influx of sodium into the cell through sodium channels down the electrochemical gradient created by the basolateral sodium pump results in depolarisation of the luminal but not the basolateral ...
Pagina 367
... Sodium is absorbed and hydrogen ions secreted at the luminal surface by an antiport mechanism ( A ) . Most bicarbonate in the filtrate is ' reabsorbed ' in this way in the proximal tubule . In the distal tubule , bicarbonate is added to ...
... Sodium is absorbed and hydrogen ions secreted at the luminal surface by an antiport mechanism ( A ) . Most bicarbonate in the filtrate is ' reabsorbed ' in this way in the proximal tubule . In the distal tubule , bicarbonate is added to ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
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acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular