PharmacologyChurchill Livingstone, 1999 - 830 pagine The aim of this work is not only to describe what drugs do, but to emphasize the mechanisms by which they act - where possible at the cellular and molecular level. Therapeutic agents have a high rate of obsolescence and many new ones are introduced each year; an appreciation of the mechanisms of action of the class of drugs to which a new agent belongs provides a starting point for understanding and using intelligently. |
Dall'interno del libro
Risultati 1-3 di 81
Pagina 59
... therapeutic index . These shortcomings mean that therapeutic index is of little value as a measure of the clinical usefulness of a drug ; digoxin , for example , used in treating cardiac failure for many years , has a notably low ...
... therapeutic index . These shortcomings mean that therapeutic index is of little value as a measure of the clinical usefulness of a drug ; digoxin , for example , used in treating cardiac failure for many years , has a notably low ...
Pagina 776
... therapeutic gene into a drug delivery system called a ' vector ' , often in the form of a suitably modified virus ( see below ) . There are two main strategies for delivering genes into patients : in vivo and ex vivo . The in vivo ...
... therapeutic gene into a drug delivery system called a ' vector ' , often in the form of a suitably modified virus ( see below ) . There are two main strategies for delivering genes into patients : in vivo and ex vivo . The in vivo ...
Pagina 779
... therapeutic protein but not of viral proteins ) and would cause persistent expression of the therapeutic gene . Viral vectors include : - — Retroviruses , which infect many different types of dividing cells and become incorporated ...
... therapeutic protein but not of viral proteins ) and would cause persistent expression of the therapeutic gene . Viral vectors include : - — Retroviruses , which infect many different types of dividing cells and become incorporated ...
Sommario
molecular aspects | 19 |
Method and measurement in pharmacology | 47 |
Absorption and distribution of drugs | 61 |
Copyright | |
46 sezioni non visualizzate
Altre edizioni - Visualizza tutto
Parole e frasi comuni
acetylcholine action potential activity agents agonists amino acids anaesthetics antagonists antidepressant antipsychotic asthma benzodiazepines binding block blood bradykinin brain Ca2+ calcium cancer cardiac cause cells chemical clinical compounds cytokines decrease depolarisation depression disease diuretics dopamine dose drugs enzyme ethanol excretion factors function GABA gastrointestinal gene glucocorticoids glucose glutamate histamine hormone important inactivation increase inflammatory inhibition inhibitors injection insulin interaction intracellular intravenous ion channels kinase leptin liver mainly mechanism of action mediators membrane metabolism metabolites molecular molecules morphine muscarinic nerve terminals nervous system neurons nicotine noradrenaline normal occurs oestrogens opioid orally oxide pathway patients peptide peripheral Pharmacokinetic Pharmacol pharmacological physiological pituitary plasma plasma concentration platelet presynaptic produce prostaglandins protein reactions receptors reduced release renal response result role secretion side-effects smooth muscle sodium steroids stimulation sympathetic synaptic synthesis therapeutic therapy tissues toxicity transmission transmitter treatment tubule tumour types unwanted effects uptake vascular